HSP 75 Antibody (TR-1A): sc-73604
- HSP 75 Antibody (TR-1A) is a mouse monoclonal IgG2a κ, cited in 13 publications, provided at 200 µg/ml
- raised against purified full length HSP 75 of human origin
- recommended for detection of HSP 75 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for HSP 75 Antibody (TR-1A) for WB applications. This reagent is now offered in a bundle with HSP 75 Antibody (TR-1A) (see ordering information below).
HSP 75 Antibody (TR-1A) is a mouse monoclonal IgG2a antibody that detects heat shock protein 75 (HSP 75) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HSP 75, also known as tumor necrosis factor type 1 receptor-associated protein (TRAP1), is a crucial member of the heat shock protein 90 family, consisting of 704 amino acids. HSP 75 primarily resides in the mitochondrion, where HSP 75 plays a vital role in maintaining cellular homeostasis by acting as a molecular chaperone. HSP 75′s ability to assist in the proper folding of proteins and the assembly of multiprotein complexes is essential for cellular function, particularly under stress conditions. Additionally, HSP 75 is involved in the regulation of apoptosis and has been implicated in various diseases, including cancer, making HSP 75 a significant target for therapeutic interventions. Anti-HSP 75 antibody (TR-1A) is an invaluable tool for researchers studying mitochondrial function and the cellular stress response, providing insights into the intricate mechanisms that govern protein homeostasis and cellular health.
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HSP 75 Antibody (TR-1A) References:
- Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells. | Im, CN. 2016. Cell Stress Chaperones. 21: 553-62. PMID: 27072803
- TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor. | Matassa, DS., et al. 2018. Genes (Basel). 9: PMID: 29621137
- Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis. | Purushottam Dharaskar, S., et al. 2020. Mitochondrion. 54: 92-101. PMID: 32784002
- The Mitochondrial Hsp90 TRAP1 and Alzheimer's Disease. | Dekker, FA. and Rüdiger, SGD. 2021. Front Mol Biosci. 8: 697913. PMID: 34222342
- The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation. | Cannino, G., et al. 2022. Cell Death Differ. 29: 2335-2346. PMID: 35614131
- The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors. | Joshi, A., et al. 2022. Biomolecules. 12: PMID: 35883436
- Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1. | Kang, S. and Kang, BH. 2022. J Med Chem. 65: 16155-16172. PMID: 36507721
- TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions. | Zhang, L., et al. 2023. Cell Death Differ. 30: 2336-2350. PMID: 37679468
- The Role of HSP90 and TRAP1 Targets on Treatment in Hepatocellular Carcinoma. | Praveen Kumar, PK., et al. 2024. Mol Biotechnol.. PMID: 38684604
- Multi-omics profiling reveal cells with novel oncogenic cluster, TRAP1low/CAMSAP3low, emerge more aggressive behavior and poor-prognosis in early-stage endometrial cancer. | Mao, X., et al. 2024. Mol Cancer. 23: 127. PMID: 38880903
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSP 75 Antibody (TR-1A) | sc-73604 | 200 µg/ml | $316.00 | |||
HSP 75 Antibody (TR-1A): m-IgG2a BP-HRP Bundle | sc-546007 | 200 µg Ab; 10 µg BP | $354.00 |