HoxC4 Antibody (G-12): sc-398460

HoxC4 Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects HoxC4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-HoxC4 antibody (G-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HoxC4, a member of the Antp HOX family, is a sequence-specific transcription factor that plays a pivotal role in embryonic development by regulating gene expression patterns that determine cell identity along the anterior-posterior axis. Nuclear localization of HoxC4 is crucial for binding to specific DNA sequences to modulate transcription, thereby influencing spatial and temporal differentiation of cells during embryogenesis. HoxC4 expression increases during lymphoid cell differentiation, indicating a significant role in molecular regulation of hematopoiesis, and appears in differentiated keratinocytes, highlighting importance in skin development and homeostasis. With versatile applications and critical biological functions, HoxC4 (G-12) monoclonal antibody serves as an essential tool for researchers studying developmental biology and gene regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

HoxC4 Antibody (G-12) References:

1. The retroviral transduction of HOXC4 into human CD34(+) cells induces an in vitro expansion of clonogenic and early progenitors.  |  Daga, A., et al. 2000. Exp Hematol. 28: 569-74. PMID: 10812247
2. The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination.  |  Kim, EC., et al. 2004. J Biol Chem. 279: 42258-69. PMID: 15252056
3. Upregulated hoxC4 induces CD14 expression during the differentiation of acute promyelocytic leukemia cells.  |  Kim, DY., et al. 2005. Leuk Lymphoma. 46: 1061-6. PMID: 16019559
4. Bioinformatics analysis of molecular mechanism of the expansion of hematopoietic stem cell transduced by HOXB4/HOXC4.  |  Xin, C., et al. 2016. Hematology. 21: 462-9. PMID: 26923762
5. Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4.  |  Wu, S., et al. 2020. Am J Physiol Cell Physiol. 318: C903-C912. PMID: 31913701
6. MicroRNA-15a Carried by Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibits the Immune Evasion of Colorectal Cancer Cells by Regulating the KDM4B/HOXC4/PD-L1 Axis.  |  Liu, L., et al. 2021. Front Cell Dev Biol. 9: 629893. PMID: 33732698
7. Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes.  |  Meazza, R., et al. 1995. Blood. 85: 2084-90. PMID: 7718879
8. Expression of the homeobox gene HOXC4 in keratinocytes of normal skin and epithelial skin tumors is correlated with differentiation.  |  Rieger, E., et al. 1994. J Invest Dermatol. 103: 341-6. PMID: 7915745
9. Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue.  |  Bijl, J., et al. 1996. Blood. 87: 1737-45. PMID: 8634419
10. HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas.  |  Bijl, JJ., et al. 1997. Am J Pathol. 151: 1067-74. PMID: 9327740
11. HOXC4, HOXC5, and HOXC6 expression in non-Hodgkin's lymphoma: preferential expression of the HOXC5 gene in primary cutaneous anaplastic T-cell and oro-gastrointestinal tract mucosa-associated B-cell lymphomas.  |  Bijl, JJ., et al. 1997. Blood. 90: 4116-25. PMID: 9354682
12. Differentiation and cell-type-restricted expression of HOXC4, HOXC5 and HOXC6 in myeloid leukemias and normal myeloid cells.  |  Bijl, JJ., et al. 1998. Leukemia. 12: 1724-32. PMID: 9823947

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HoxC4 Antibody (G-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HoxC4 Antibody (G-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HoxC4 Antibody (G-12) Specifications

Alternate Product Name: HoxC4

Product Clone Name: G-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 59-134

Epitope Target: HoxC4

Epitope Species: human

Product Reactivity/Detection: HoxC4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HoxC4 Antibody (G-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin