HOOK2 Antibody (E-3): sc-374169

HOOK2 Antibody (E-3) is a mouse monoclonal IgG2b antibody that detects HOOK2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HOOK2 is a crucial member of the HOOK protein family, which plays a significant role in the spatial organization of membrane-trafficking systems by interacting with microtubules and various organelles. HOOK2 (E-3) antibody recognizes a protein that is 719 amino acids long and forms homodimers, likely through its central coiled-coil domain, which is essential for structural integrity and function. HOOK2 localizes to specific subcellular structures that do not correspond to typical organelles such as early or late endosomes, mitochondria, or the Golgi complex, highlighting a unique role in cellular organization. HOOK2 expression is particularly strong in the larynx and esophagus, and anti-HOOK2 antibody (E-3) can help study potential tumorigenic processes, as HOOK2 may associate with other proteins like SURF1 and Zic2, which are also considered potential esophageal cancer tumor antigens. HOOK2′s interaction with these proteins underscores its importance in cellular signaling pathways and its potential as a biomarker for esophageal cancer, making anti-HOOK2 antibody (E-3) a valuable tool for researchers studying these critical processes.

The preferred HOOK2 antibody is HOOK2 Antibody (G-4): sc-365716.