HNF-3γ Antibody (G-2): sc-271229

HNF-3γ Antibody (G-2) is a mouse monoclonal IgG2a antibody that detects HNF-3γ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HNF-3γ, a member of the hepatocyte nuclear factor family, plays a crucial role in regulating gene expression in various tissues, particularly in the liver, where HNF-3γ is essential for the transcription of genes involved in metabolic processes. HNF-3γ is primarily located in the nucleus, where HNF-3γ binds to specific DNA sequences to activate or repress target genes, thereby influencing cellular functions such as differentiation and metabolism. This nuclear localization allows HNF-3γ to exert regulatory effects directly on gene transcription, impacting processes like glucose homeostasis and lipid metabolism. Additionally, HNF-3γ interacts with other transcription factors and co-regulators, which further modulates activity and expression of downstream genes. Such coordination with other proteins underscores HNF-3γ′s importance in maintaining cellular function and homeostasis, making HNF-3γ a significant target for research in metabolic diseases and developmental biology. anti-HNF-3γ antibody (G-2) is an invaluable tool for researchers aiming to explore these intricate roles in various biological contexts.

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HNF-3γ Antibody (G-2) References:

1. Hepatoprotective action of adenovirus-transferred HNF-3gamma gene in acute liver injury caused by CCl(4).  |  Nakamura, T., et al. 1999. FEBS Lett. 459: 1-4. PMID: 10508906
2. Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast.  |  Shen, W., et al. 2001. J Biol Chem. 276: 42812-7. PMID: 11546810
3. FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation.  |  Seiliez, I., et al. 2006. Dev Biol. 290: 152-63. PMID: 16364286
4. Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.  |  Park, SW., et al. 2009. Am J Respir Crit Care Med. 180: 603-10. PMID: 19628779
5. Regulation of testicular steroidogenesis by Foxa3 via transcriptional modulation of ERα signaling in type 2 diabetes mellitus (T2DM).  |  Zhao, Y., et al. 2017. Biochem Biophys Res Commun. 490: 786-793. PMID: 28645613
6. m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance.  |  Zhou, T., et al. 2020. Signal Transduct Target Ther. 5: 296. PMID: 33361765
7. FOXA3 Polymorphisms Are Associated with Metabolic Parameters in Individuals with Subclinical Atherosclerosis and Healthy Controls-The GEA Mexican Study.  |  Vargas-Alarcón, G., et al. 2022. Biomolecules. 12: PMID: 35625529
8. Impact of Fetal Exposure to Endocrine Disrupting Chemical Mixtures on FOXA3 Gene and Protein Expression in Adult Rat Testes.  |  Walker, C., et al. 2023. Int J Mol Sci. 24: PMID: 36674726
9. HOXC10 promotes esophageal squamous cell carcinoma progression by targeting FOXA3 and indicates poor survival outcome.  |  He, X., et al. 2023. Heliyon. 9: e21056. PMID: 37876483
10. The Effect of FOXA3 Overexpression on Hepatocyte Differentiation and Liver Regeneration in a Fah cKO Mouse Model.  |  Li, S., et al. 2025. Cell Mol Gastroenterol Hepatol. 19: 101438. PMID: 39662671

The preferred HNF-3γ antibody is HNF-3γ Antibody (A-2): sc-74424.