HNF-1 α Antibodies

Santa Cruz Biotechnology features a diverse variety of HNF-1 α monoclonal antibodies for research focused on understanding this critical transcription factor. HNF-1 α Antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). HNF-1 α (Hepatocyte Nuclear Factor 1 Alpha) plays an essential role in regulating genes involved in glucose metabolism and insulin secretion, making it a key player in maintaining metabolic homeostasis. Dysregulation of HNF-1 α has been linked to various metabolic disorders, including maturity-onset diabetes of the young (MODY) and other conditions affecting liver function. Understanding HNF-1 α function and regulation opens new possibilities for therapeutic interventions in metabolic diseases. Researchers can utilize specific conjugates including horseradish peroxidase (HRP), phycoerythrin (PE), and fluorescein isothiocyanate (FITC) for enhanced detection and visualization. Current investigations focus on HNF-1 α's role in pancreatic beta-cell development and function. Ongoing studies explore the relationship between HNF-1 α mutations and diabetes progression. Santa Cruz Biotechnology monoclonal antibodies for HNF-1 α support researchers worldwide in advancing our understanding of metabolic disease mechanisms and potential treatments.