HNF-1α Antibody (2): sc-135939

HNF-1α Antibody (2) is a mouse monoclonal IgG1 antibody that detects HNF-1α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). HNF-1α is a crucial transcription factor that plays a significant role in regulating gene expression in the liver and other tissues, including the kidney and small intestine. HNF-1α is essential for maintaining metabolic homeostasis and is involved in the transcriptional regulation of various genes vital for liver function, such as those involved in glucose and lipid metabolism. Proper functioning of HNF-1α is particularly important because mutations in the HNF-1α gene can lead to maturity-onset diabetes of the young (MODY), a form of diabetes characterized by early onset and a strong genetic component. Additionally, HNF-1α interacts with other members of the hepatocyte nuclear factor family, such as HNF-4α, to coordinate the expression of genes necessary for liver development and function. HNF-1α′s ability to bind to specific DNA sequences in the promoter regions of target genes underscores its importance in the regulation of metabolic pathways, making anti-HNF-1α antibody (2) an invaluable tool for researchers studying these pathways and their implications in health and disease.

The preferred HNF-1α antibody is HNF-1α Antibody (F-7): sc-393925.