HNF-1α Antibody (B-3): sc-393668
- HNF-1α Antibody (B-3) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 618-631 at the C-terminus of HNF-1α of human origin
- recommended for detection of HNF-1α of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and porcine
- TransCruz reagent for ChIP application (sc-393668 X, 200 µg/0.1 ml)
- See HNF-1α (F-7): sc-393925 for HNF-1α antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HNF-1α Antibody (B-3) for WB applications. These reagents are now offered in bundles with HNF-1α Antibody (B-3) (see ordering information below).
HNF-1α Antibody (B-3) is a mouse monoclonal IgG1 antibody that detects HNF-1α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HNF-1α, a member of the hepatocyte nuclear factor family, plays a crucial role in regulating the transcription of genes involved in liver function and development, as well as in other tissues like the kidney and small intestine. Anti-HNF-1α antibody (B-3) targets a protein primarily located in the nucleus, where HNF-1α binds to specific DNA sequences to activate or repress target genes, making HNF-1α essential for maintaining metabolic homeostasis and proper organ function. Nuclear localization of HNF-1α directly influences the expression of genes critical for glucose metabolism and insulin secretion, thereby impacting overall metabolic health. HNF-1α interacts with other transcription factors, such as HNF-4α and HNF-3β, to form a regulatory network that ensures precise control of gene expression during development and in adult tissues. HNF-1α monoclonal antibody (B-3) serves as an invaluable tool for researchers studying metabolic diseases, liver function, and transcriptional regulation, providing insights into molecular mechanisms underlying these processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HNF-1α Antibody (B-3) | sc-393668 | 200 µg/ml | $322.00 | |||
HNF-1α Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-538277 | 200 µg Ab; 10 µg BP | $361.00 | |||
HNF-1α Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-535855 | 200 µg Ab; 40 µg BP | $361.00 | |||
HNF-1α Antibody (B-3): m-IgG1 BP-HRP Bundle | sc-545620 | 200 µg Ab; 20 µg BP | $361.00 | |||
HNF-1α (B-3) Neutralizing Peptide | sc-393668 P | 100 µg/0.5 ml | $69.00 | |||
HNF-1α Antibody (B-3) X | sc-393668 X | 200 µg/0.1 ml | $322.00 |