HNF-3γ Antibody (D-4): sc-166703
- HNF-3γ Antibody (D-4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 8-26 at the N-terminus of HNF-3γ of human origin
- recommended for detection of HNF-3γ of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-166703 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HNF-3γ Antibody (D-4) for WB applications. These reagents are now offered in bundles with HNF-3γ Antibody (D-4) (see ordering information below).
HNF-3γ Antibody (D-4) is a mouse monoclonal IgG1 antibody that detects HNF-3γ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HNF-3γ, a member of the hepatocyte nuclear factor family, plays a crucial role in regulating gene expression in various tissues, particularly in the liver, where HNF-3γ influences the transcription of genes essential for metabolic processes. HNF-3γ is primarily located in the nucleus, where HNF-3γ binds to specific DNA sequences to activate or repress target genes, thereby impacting cellular functions such as differentiation and development. Nuclear localization of HNF-3γ is vital for orchestrating transcriptional programs necessary for proper liver function and embryonic development. HNF-3γ interacts with other transcription factors, including HNF-1 and HNF-4, to form a complex regulatory network that ensures precise control of gene expression in response to physiological signals. Anti-HNF-3γ antibody (D-4) is an invaluable tool for researchers studying gene regulation mechanisms and liver-related disease pathophysiology.
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HNF-3γ Antibody (D-4) References:
- Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3. | Behr, R., et al. 2007. Dev Biol. 306: 636-45. PMID: 17488644
- Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. | Chen, G., et al. 2014. Am J Respir Crit Care Med. 189: 301-13. PMID: 24392884
- Opposing Roles of FoxA1 and FoxA3 in Intrahepatic Cholangiocarcinoma Progression. | Thanan, R., et al. 2020. Int J Mol Sci. 21: PMID: 32151057
- Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway. | Liu, Q., et al. 2020. Exp Gerontol. 139: 111053. PMID: 32768436
- Forkhead-box A3 (FOXA3) represses cancer stemness and partially potentiates chemosensitivity by targeting metastasis-associated in colon cancer 1 (MACC1) signaling pathway in colorectal cancer cells. | Li, N., et al. 2020. Curr Cancer Drug Targets.. PMID: 33292133
- Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression. | Zhan, X. and Zhao, A. 2021. J Clin Lab Anal. 35: e23686. PMID: 33368532
- FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis. | Kim, H., et al. 2021. Int J Endocrinol. 2021: 6619447. PMID: 33763129
- Hypoxia-induced LncRNA DACT3-AS1 upregulates PKM2 to promote metastasis in hepatocellular carcinoma through the HDAC2/FOXA3 pathway. | Wang, L., et al. 2022. Exp Mol Med. 54: 848-860. PMID: 35764883
- Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl4-induced liver fibrosis in mice. | Shu, G., et al. 2023. Food Funct. 14: 10591-10604. PMID: 37955610
- Hepatic FOXA3 overexpression prevents Western diet-induced obesity and MASH through TGR5. | Gopoju, R., et al. 2024. J Lipid Res. 65: 100527. PMID: 38447926
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HNF-3γ Antibody (D-4) | sc-166703 | 200 µg/ml | $322.00 | |||
HNF-3γ Antibody (D-4): m-IgG Fc BP-HRP Bundle | sc-537524 | 200 µg Ab; 10 µg BP | $361.00 | |||
HNF-3γ Antibody (D-4): m-IgGκ BP-HRP Bundle | sc-534815 | 200 µg Ab; 40 µg BP | $361.00 | |||
HNF-3γ Antibody (D-4): m-IgG1 BP-HRP Bundle | sc-545213 | 200 µg Ab; 20 µg BP | $361.00 | |||
HNF-3γ (D-4) Neutralizing Peptide | sc-166703 P | 100 µg/0.5 ml | $69.00 | |||
HNF-3γ Antibody (D-4) X | sc-166703 X | 200 µg/0.1 ml | $322.00 |