Histone H10 Antibody (27): sc-56694
- Histone H10 Antibody (27) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against Histone H10 (H1 zero) of bovine origin
- recommended for detection of Histone H10 of mouse, rat, human, bovine, Xenopus and sea urchin origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Histone H10 Antibody (27) for WB applications. These reagents are now offered in bundles with Histone H10 Antibody (27) (see ordering information below).
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Histone H10 Antibody (27) is a mouse monoclonal IgG1 antibody that detects Histone H10 in mouse, rat, human, bovine, and Xenopus samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Histone H10 is a lysine-rich member of the H1 family of linker histones, playing a crucial role in the organization and compaction of chromatin by interacting with linker DNA between nucleosomes. This unique variant serves as a replacement linker histone, expressed and incorporated into chromatin during terminal stages of differentiation or in cells with low rates of division, distinguishing Histone H10 from other somatic H1 histones that are typically replication-dependent. Histone H10 is widely expressed across various tissues in most vertebrates, which underscores a fundamental role in cellular processes. The gene encoding Histone H10, H1F0, is located on human chromosome 22q13.1 and is intronless, reflecting evolutionary conservation. Histone H10 undergoes various post-translational modifications, such as methylation, acetylation, and phosphorylation, primarily on N-terminal tails, which are critical for regulating chromatin structure and function, thereby influencing gene expression and cellular differentiation.
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Histone H10 Antibody (27) References:
- Immunohistochemical demonstration of histone H1(0) in human breast carcinoma. | Kostova, NN., et al. 2005. Histochem Cell Biol. 124: 435-43. PMID: 16158288
- The differentiation-associated linker histone, H1.0, during the in vitro aging and senescence of human diploid fibroblasts. | Sekeri-Pataryas, KE. and Sourlingas, TG. 2007. Ann N Y Acad Sci. 1100: 361-7. PMID: 17460199
- Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus. | Kalashnikova, AA., et al. 2013. Nucleic Acids Res. 41: 4026-35. PMID: 23435226
- Histone H1.0--a potential molecular marker with prognostic value for patients with malignant gliomas. | Gabrovsky, N., et al. 2013. Acta Neurochir (Wien). 155: 1437-42. PMID: 23812966
- The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity. | Torres, CM., et al. 2016. Science. 353: PMID: 27708074
- Genome-wide distribution of linker histone H1.0 is independent of MeCP2. | Ito-Ishida, A., et al. 2018. Nat Neurosci. 21: 794-798. PMID: 29802390
- Identification and Analysis of Six Phosphorylation Sites Within the Xenopus laevis Linker Histone H1.0 C-Terminal Domain Indicate Distinct Effects on Nucleosome Structure. | Hao, F., et al. 2022. Mol Cell Proteomics. 21: 100250. PMID: 35618225
- Histone H1.0 couples cellular mechanical behaviors to chromatin structure. | Hu, S., et al. 2024. Nat Cardiovasc Res. 3: 441-459. PMID: 38765203
- IFRD1 promotes tumor cells 'low-cost' survival under glutamine starvation via inhibiting histone H1.0 nucleophagy. | Huang, Y., et al. 2024. Cell Discov. 10: 57. PMID: 38802351
- Linker histone H1.0 loads onto nucleosomes through multiple pathways that are facilitated by histone chaperones. | Akbari, E., et al. 2025. bioRxiv.. PMID: 40060531
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Histone H10 Antibody (27) | sc-56694 | 200 µg/ml | $316.00 | |||
Histone H10 Antibody (27): m-IgG Fc BP-HRP Bundle | sc-537115 | 200 µg Ab; 10 µg BP | $354.00 | |||
Histone H10 Antibody (27): m-IgGκ BP-HRP Bundle | sc-534307 | 200 µg Ab; 40 µg BP | $354.00 | |||
Histone H10 Antibody (27): m-IgG1 BP-HRP Bundle | sc-545013 | 200 µg Ab; 20 µg BP | $354.00 |