Date published: 2026-1-9

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Histone H3 Antibodies

Santa Cruz Biotechnology provides a broad selection of Histone H3 monoclonal antibodies for research in epigenetics and chromatin biology. Histone H3 Antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Histone H3 plays a central role in the packaging of DNA into chromatin, influencing gene expression and DNA repair processes. Modifications to Histone H3, such as methylation and acetylation, are key regulatory mechanisms that impact cellular functions and are implicated in various diseases, including cancer. Understanding the dynamics of Histone H3 is essential for elucidating the regulatory networks that govern cellular behavior. Researchers can investigate specific Histone H3 modifications to better understand their impact on chromatin structure and gene regulation. Advanced research techniques using Histone H3 monoclonal antibodies enable detailed analysis of epigenetic modifications and their biological significance. The high specificity of Histone H3 monoclonal antibodies from Santa Cruz Biotechnology supports researchers worldwide in advancing epigenetic and chromatin biology studies.

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Histone H3 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Ac-Histone H3 Antibody (AH3-120)

sc-56616mouse IgG1 κ(h)WB, IP, IFm, r, h, Drosophila, Xenopus, C. elegans and bovine
39
(17)

Ac-Histone H3 Antibody (D-4)

sc-518011mouse IgG3 κ1-28 (h)WB, IP, IF, ELISAm, r, h
13
(4)

Histone H3F3C Antibody (1B1-B2)

sc-517385mouse IgG3 κC-Terminal (h)WB, IPm, r, h
2
(0)

Histone H3 Antibody (1G1)

sc-517576mouse IgG(h)WB, IFm, r, h
86
(10)

Dimethyl Histone H3 Antibody (3C2)

sc-517567mouse IgG(h)WBm, r, h
1
(0)

Dimethyl Histone H3 Antibody (3B12)

sc-517568mouse IgG(h)WB, IPm, r, h

new

(0)

Monomethyl Histone H3 Antibody (1C2)

sc-517569mouse IgG(h)WBm, r, h

new

(0)

Trimethyl Histone H3 Antibody (6F12-H4)

sc-130356mouse IgG16-16 (h)WB, IP, IFm, r, h
6
(10)

Trimethyl Histone H3 Antibody (3G3)

sc-517570mouse IgG(h)WBm, r, h

new

(0)

Phospho-Specific Histone H3 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

p-Histone H3 Antibody (C-2)

sc-374669mouse IgG2b κSer 28 (h)WB, IP, IF, ELISAm, r, h
29
(10)

p-Histone H3 Antibody (HTA28)

sc-56745rat IgG2aSer 28 (h)WB, IP, IF, FCMm, r, h and bovine
2
(2)

p-Ac-Histone H3 Antibody (APH3-64)

sc-56739mouse IgG2a κLys 9/Ser 10 (h)WB, IPm, r, h, Drosophila, Xenopus , C. elegans and bovine
4
(1)

Histone H3 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Histone H3.3A CRISPR/Cas9 KO Plasmid (h)

sc-416802hGene KnockoutGFP0
(0)

Histone H3.3A HDR Plasmid (h)

sc-416802-HDRhHomology Directed RepairPuromycin0
(0)

Histone H3.3A Double Nickase Plasmid (h)

sc-416802-NIChGene KnockoutPuromycin0
(0)

Histone H3.3A Double Nickase Plasmid (h2)

sc-416802-NIC-2hGene KnockoutPuromycin0
(0)

Histone H3.3A CRISPR/Cas9 KO Plasmid (m)

sc-420787mGene KnockoutGFP0
(0)

Histone H3.3A HDR Plasmid (m)

sc-420787-HDRmHomology Directed RepairPuromycin0
(0)

Histone H3.3A Double Nickase Plasmid (m)

sc-420787-NICmGene KnockoutPuromycin0
(0)

Histone H3.3A Double Nickase Plasmid (m2)

sc-420787-NIC-2mGene KnockoutPuromycin0
(0)

Histone H3.3B CRISPR/Cas9 KO Plasmid (h)

sc-410815hGene KnockoutGFP0
(0)

Histone H3.3B HDR Plasmid (h)

sc-410815-HDRhHomology Directed RepairPuromycin0
(0)

Histone H3.3B Double Nickase Plasmid (h)

sc-410815-NIChGene KnockoutPuromycin0
(0)

Histone H3.3B Double Nickase Plasmid (h2)

sc-410815-NIC-2hGene KnockoutPuromycin0
(0)

Histone H3.3B CRISPR/Cas9 KO Plasmid (m)

sc-420788mGene KnockoutGFP0
(0)

Histone H3.3B HDR Plasmid (m)

sc-420788-HDRmHomology Directed RepairPuromycin0
(0)

Histone H3.3B Double Nickase Plasmid (m)

sc-420788-NICmGene KnockoutPuromycin0
(0)

Histone H3.3B Double Nickase Plasmid (m2)

sc-420788-NIC-2mGene KnockoutPuromycin0
(0)

Histone H3F3C CRISPR/Cas9 KO Plasmid (h)

sc-416021hGene KnockoutGFP0
(0)

Histone H3F3C HDR Plasmid (h)

sc-416021-HDRhHomology Directed RepairPuromycin0
(0)

Histone H3F3C Double Nickase Plasmid (h)

sc-416021-NIChGene KnockoutPuromycin0
(0)

Histone H3F3C Double Nickase Plasmid (h2)

sc-416021-NIC-2hGene KnockoutPuromycin0
(0)

Histone H3 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Histone H3.3A CRISPR Activation Plasmid (h)

sc-416802-ACThGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3A CRISPR Activation Plasmid (h2)

sc-416802-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3A Lentiviral Activation Particles (h)

sc-416802-LAChGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3A Lentiviral Activation Particles (h2)

sc-416802-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3A CRISPR Activation Plasmid (m)

sc-420787-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3A CRISPR Activation Plasmid (m2)

sc-420787-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3A Lentiviral Activation Particles (m)

sc-420787-LACmGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3A Lentiviral Activation Particles (m2)

sc-420787-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3B CRISPR Activation Plasmid (h)

sc-410815-ACThGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3B CRISPR Activation Plasmid (h2)

sc-410815-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3B Lentiviral Activation Particles (h)

sc-410815-LAChGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3B Lentiviral Activation Particles (h2)

sc-410815-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3B CRISPR Activation Plasmid (m)

sc-420788-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3B CRISPR Activation Plasmid (m2)

sc-420788-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3B Lentiviral Activation Particles (m)

sc-420788-LACmGene ActivationPuro, Blast, Hygro0
(0)

Histone H3.3B Lentiviral Activation Particles (m2)

sc-420788-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Histone H3F3C CRISPR Activation Plasmid (h)

sc-416021-ACThGene ActivationPuro, Blast, Hygro0
(0)

Histone H3F3C CRISPR Activation Plasmid (h2)

sc-416021-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Histone H3F3C Lentiviral Activation Particles (h)

sc-416021-LAChGene ActivationPuro, Blast, Hygro0
(0)

Histone H3F3C Lentiviral Activation Particles (h2)

sc-416021-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Histone H3 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Histone H3.3A siRNA (h)

sc-105523hGene SilencingN/A0
(0)

Histone H3.3A shRNA Plasmid (h)

sc-105523-SHhGene SilencingPuromycin0
(0)

Histone H3.3A shRNA (h) Lentiviral Particles

sc-105523-VhGene SilencingPuromycin0
(0)

Histone H3.3A siRNA (m)

sc-146037mGene SilencingN/A0
(0)

Histone H3.3A shRNA Plasmid (m)

sc-146037-SHmGene SilencingPuromycin0
(0)

Histone H3.3A shRNA (m) Lentiviral Particles

sc-146037-VmGene SilencingPuromycin0
(0)

Histone H3.3B siRNA (h)

sc-105524hGene SilencingN/A0
(0)

Histone H3.3B shRNA Plasmid (h)

sc-105524-SHhGene SilencingPuromycin0
(0)

Histone H3.3B shRNA (h) Lentiviral Particles

sc-105524-VhGene SilencingPuromycin0
(0)

Histone H3.3B siRNA (m)

sc-146038mGene SilencingN/A0
(0)

Histone H3.3B shRNA Plasmid (m)

sc-146038-SHmGene SilencingPuromycin0
(0)

Histone H3.3B shRNA (m) Lentiviral Particles

sc-146038-VmGene SilencingPuromycin0
(0)

Histone H3F3C siRNA (h)

sc-105721hGene SilencingN/A0
(0)

Histone H3F3C shRNA Plasmid (h)

sc-105721-SHhGene SilencingPuromycin0
(0)

Histone H3F3C shRNA (h) Lentiviral Particles

sc-105721-VhGene SilencingPuromycin0
(0)