HIGD2A Antibody (A-6): sc-390505
- HIGD2A Antibody (A-6) is a mouse monoclonal IgG2a κ HIGD2A antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 13-47 within an N-terminal cytoplasmic domain of HIGD2A of human origin
- HIGD2A Antibody (A-6) is recommended for detection of HIGD2A of mouse, rat, human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-HIGD2A Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HIGD2A Antibody (A-6) for WB and IHC(P) applications. These reagents are now offered in bundles with HIGD2A Antibody (A-6) (see ordering information below).
QUICK LINKS
HIGD2A Antibody (A-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects HIGD2A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-HIGD2A antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HIGD2A protein, also known as HIG1 domain family member 2A, is a 106 amino acid multi-pass membrane protein characterized by one HIG1 domain, which plays a crucial role in cellular responses to hypoxia. HIGD2A (A-6) antibody targets a protein primarily located in the endoplasmic reticulum and involved in regulating cellular metabolism under low oxygen conditions, making HIGD2A essential for maintaining cellular homeostasis and survival in hypoxic environments. The gene encoding HIGD2A is situated on human chromosome 5, a region comprising nearly 6% of the human genome and associated with various genetic disorders, including Cockayne syndrome and familial adenomatous polyposis. Understanding HIGD2A function and localization is vital for elucidating its role in disease mechanisms and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HIGD2A Antibody (A-6) References:
- Familial adenomatous polyposis and mental retardation caused by a de novo chromosomal deletion at 5q15-q22: report of a case. | Finch, R., et al. 2005. Dis Colon Rectum. 48: 2148-52. PMID: 16228830
- Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. | Anindya, R., et al. 2007. Mol Cell. 28: 386-97. PMID: 17996703
- Haematological & molecular profile of acute myelogenous leukaemia in India. | Sazawal, S., et al. 2009. Indian J Med Res. 129: 256-61. PMID: 19491417
- Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities. | Ravandi, F., et al. 2009. Cancer. 115: 5746-51. PMID: 19795507
- Characterization of a de novo complex chromosomal rearrangement in a patient with cri-du-chat and trisomy 5p syndromes. | Vera-Carbonell, A., et al. 2009. Am J Med Genet A. 149A: 2513-21. PMID: 19842199
- The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon. | Edwards, SJ., et al. 1997. Am J Hum Genet. 60: 515-24. PMID: 9042910
- Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome. | Crawford, MJ., et al. 1997. Mamm Genome. 8: 841-5. PMID: 9337397
- Confirmation of homozygosity for a single nucleotide substitution mutation in a Cockayne syndrome patient using monoallelic mutation analysis in somatic cell hybrids. | McDaniel, LD., et al. 1997. Hum Mutat. 10: 317-21. PMID: 9338586
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIGD2A Antibody (A-6) | sc-390505 | 200 µg/ml | $316.00 | |||
HIGD2A Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-530174 | 200 µg Ab; 10 µg BP | $354.00 | |||
HIGD2A Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-523562 | 200 µg Ab, 40 µg BP | $354.00 | |||
HIGD2A Antibody (A-6): m-IgG2a BP-HRP Bundle | sc-547450 | 200 µg Ab; 10 µg BP | $354.00 | |||
HIGD2A Antibody (A-6) AC | sc-390505 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HIGD2A Antibody (A-6) HRP | sc-390505 HRP | 200 µg/ml | $316.00 | |||
HIGD2A Antibody (A-6) FITC | sc-390505 FITC | 200 µg/ml | $330.00 | |||
HIGD2A Antibody (A-6) PE | sc-390505 PE | 200 µg/ml | $343.00 | |||
HIGD2A Antibody (A-6) Alexa Fluor® 488 | sc-390505 AF488 | 200 µg/ml | $357.00 | |||
HIGD2A Antibody (A-6) Alexa Fluor® 546 | sc-390505 AF546 | 200 µg/ml | $357.00 | |||
HIGD2A Antibody (A-6) Alexa Fluor® 594 | sc-390505 AF594 | 200 µg/ml | $357.00 | |||
HIGD2A Antibody (A-6) Alexa Fluor® 647 | sc-390505 AF647 | 200 µg/ml | $357.00 | |||
HIGD2A Antibody (A-6) Alexa Fluor® 680 | sc-390505 AF680 | 200 µg/ml | $357.00 | |||
HIGD2A Antibody (A-6) Alexa Fluor® 790 | sc-390505 AF790 | 200 µg/ml | $357.00 | |||
HIGD2A (A-6) Neutralizing Peptide | sc-390505 P | 100 µg/0.5 ml | $68.00 |