HERPUD2 Antibody (D-12): sc-398583
- HERPUD2 Antibody (D-12) is a mouse monoclonal IgG2b κ HERPUD2 antibody provided at 200 µg/ml
- raised against amino acids 145-202 mapping within an internal region of HERPUD2 of human origin
- HERPUD2 Antibody (D-12) is recommended for detection of HERPUD2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-HERPUD2 Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HERPUD2 Antibody (D-12) for WB applications. These reagents are now offered in bundles with HERPUD2 Antibody (D-12) (see ordering information below).
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HERPUD2 Antibody (D-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects HERPUD2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HERPUD2 (D-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HERPUD2, or Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2, is a crucial component of the endoplasmic reticulum (ER) stress response, which is activated by the accumulation of misfolded proteins within the ER. HERPUD2 plays a significant role in the unfolded protein response (UPR) pathway, which is essential for maintaining cellular homeostasis. HERPUD2 is a 406 amino acid single-pass membrane protein that contains an N-terminal ubiquitin-like domain, which is vital for function in the ER-associated protein degradation (ERAD) system. The UPR is characterized by three key events: the inhibition of translation to prevent further protein accumulation, the upregulation of polypeptide-folding proteins, and the degradation of misfolded proteins. HERPUD2 helps to mitigate the detrimental effects of ER stress, thereby ensuring proper protein folding and function, which is critical for cell survival and function under stress conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HERPUD2 Antibody (D-12) References:
- The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway. | van Laar, T., et al. 2000. FEBS Lett. 469: 123-31. PMID: 10708769
- Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. | Kokame, K., et al. 2000. J Biol Chem. 275: 32846-53. PMID: 10922362
- Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. | Kokame, K., et al. 2001. J Biol Chem. 276: 9199-205. PMID: 11112790
- Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. | Sai, X., et al. 2002. J Biol Chem. 277: 12915-20. PMID: 11799129
- The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. | Schulze, A., et al. 2005. J Mol Biol. 354: 1021-7. PMID: 16289116
- Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. | Liang, G., et al. 2006. Mol Cell Biol. 26: 7999-8010. PMID: 16940180
- The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp. | Tuvia, S., et al. 2007. J Cell Biol. 177: 51-61. PMID: 17420289
- Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp. | Okuda-Shimizu, Y. and Hendershot, LM. 2007. Mol Cell. 28: 544-54. PMID: 18042451
- Herp enhances ER-associated protein degradation by recruiting ubiquilins. | Kim, TY., et al. 2008. Biochem Biophys Res Commun. 369: 741-6. PMID: 18307982
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HERPUD2 Antibody (D-12) | sc-398583 | 200 µg/ml | $322.00 | |||
HERPUD2 Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-530854 | 200 µg Ab; 10 µg BP | $361.00 | |||
HERPUD2 Antibody (D-12): m-IgGκ BP-HRP Bundle | sc-524403 | 200 µg Ab, 40 µg BP | $361.00 | |||
HERPUD2 Antibody (D-12): m-IgG2b BP-HRP Bundle | sc-550233 | 200 µg Ab; 10 µg BP | $361.00 | |||
HERPUD2 Antibody (D-12) AC | sc-398583 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HERPUD2 Antibody (D-12) HRP | sc-398583 HRP | 200 µg/ml | $322.00 | |||
HERPUD2 Antibody (D-12) FITC | sc-398583 FITC | 200 µg/ml | $336.00 | |||
HERPUD2 Antibody (D-12) PE | sc-398583 PE | 200 µg/ml | $349.00 | |||
HERPUD2 Antibody (D-12) Alexa Fluor® 488 | sc-398583 AF488 | 200 µg/ml | $364.00 | |||
HERPUD2 Antibody (D-12) Alexa Fluor® 546 | sc-398583 AF546 | 200 µg/ml | $364.00 | |||
HERPUD2 Antibody (D-12) Alexa Fluor® 594 | sc-398583 AF594 | 200 µg/ml | $364.00 | |||
HERPUD2 Antibody (D-12) Alexa Fluor® 647 | sc-398583 AF647 | 200 µg/ml | $364.00 | |||
HERPUD2 Antibody (D-12) Alexa Fluor® 680 | sc-398583 AF680 | 200 µg/ml | $364.00 | |||
HERPUD2 Antibody (D-12) Alexa Fluor® 790 | sc-398583 AF790 | 200 µg/ml | $364.00 |