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Histone Deacetylase 4 (HDAC4) Antibody (D-1): sc-48390

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Datasheets
  • Histone Deacetylase 4 (HDAC4) Antibody (D-1) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
  • raised against amino acids 530-631 of HDAC4 of human origin
  • recommended for detection of HDAC4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
  • See Histone Deacetylase 4 (A-4): sc-46672 for Histone Deacetylase 4 (HDAC4) antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Histone Deacetylase 4 (HDAC4) Antibody (D-1) for WB and IHC(P) applications. These reagents are now offered in bundles with Histone Deacetylase 4 (HDAC4) Antibody (D-1) (see ordering information below).
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HDAC4 Antibody (D-1) is a mouse monoclonal IgG1 antibody that detects HDAC4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). HDAC4, or Histone Deacetylase 4, plays a crucial role in gene expression regulation by removing acetyl groups from histones, leading to chromatin condensation and transcriptional repression. This function maintains cellular homeostasis and regulates processes such as differentiation, proliferation, and apoptosis. Dysregulation of HDAC4 has been implicated in various diseases, including cancer and neurodegenerative disorders, making anti-HDAC4 antibody (D-1) an important tool for therapeutic research. HDAC4 interacts with several specific proteins, including transcription factors and co-repressors, which further modulate activity and influence downstream signaling pathways. HDAC4′s ability to shuttle between nucleus and cytoplasm adds complexity to regulatory functions, highlighting significance in cellular signaling and gene expression control.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Histone Deacetylase 4 (HDAC4) Antibody (D-1)

sc-48390
200 µg/ml
$322.00

Histone Deacetylase 4 (HDAC4) Antibody (D-1): m-IgG Fc BP-HRP Bundle

sc-536824
200 µg Ab; 10 µg BP
$361.00

Histone Deacetylase 4 (HDAC4) Antibody (D-1): m-IgGκ BP-HRP Bundle

sc-533991
200 µg Ab; 40 µg BP
$361.00

Histone Deacetylase 4 (HDAC4) Antibody (D-1): m-IgG1 BP-HRP Bundle

sc-544842
200 µg Ab; 20 µg BP
$361.00

Can HDAC4 (D-1): sc-48390 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes, HDAC4 (D-1): sc-48390 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 4 out of 5 by from Good ProductWe used this antibody for WB and IF with mouse brain tissue and it works very well.
Date published: 2019-06-13
Rated 4 out of 5 by from Strong immunoperoxidase staining of formalin fixedStrong immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tissue showing cytoplasmic staining of glandular cells. -SCBT QC
Date published: 2015-01-30
Rated 4 out of 5 by from Immunofluorescence publication using hUCBImmunofluorescence publication using hUCB-MSCs samples -SCBT Publication Review
Date published: 2015-01-24
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Histone Deacetylase 4 (HDAC4) Antibody (D-1) is rated 4.0 out of 5 by 3.
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