Histone Deacetylase 4 (HDAC4) Antibody (A-4): sc-46672

HDAC4 Antibody (A-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects HDAC4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). HDAC4 (A-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HDAC4 protein plays a crucial role in the regulation of gene expression through function as a histone deacetylase, which removes acetyl groups from lysine residues on histones, leading to chromatin condensation and transcriptional repression. This process is vital for maintaining cellular homeostasis and regulating developmental processes, as aberrant expression or activity of HDAC4 has been implicated in various diseases, including cancer and neurodegenerative disorders. Additionally, HDAC4 interacts with several other proteins, such as transcription factor MEF2, which is involved in muscle differentiation and neuronal function, highlighting importance in cellular signaling pathways. Using anti-HDAC4 antibody (A-4) in research can provide valuable insights into regulatory mechanisms of gene expression and potential therapeutic targets for diseases associated with dysregulated histone acetylation.

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Histone Deacetylase 4 (HDAC4) Antibody (A-4) References:

1. Three proteins define a class of human histone deacetylases related to yeast Hda1p.  |  Grozinger, CM., et al. 1999. Proc Natl Acad Sci U S A. 96: 4868-73. PMID: 10220385
2. MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4.  |  Wu, H., et al. 2020. Autophagy. 16: 683-697. PMID: 31242129
3. HDAC4 Inhibitors as Antivascular Senescence Therapeutics.  |  Huang, C., et al. 2022. Oxid Med Cell Longev. 2022: 3087916. PMID: 35814270
4. m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop.  |  Liu, X., et al. 2023. Oncogene. 42: 2047-2060. PMID: 37149664
5. Nucleosome structural changes due to acetylation.  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
6. A positive role for histone acetylation in transcription factor access to nucleosomal DNA.  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
7. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
8. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.  |  Taunton, J., et al. 1996. Science. 272: 408-11. PMID: 8602529
9. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.  |  Verreault, A., et al. 1998. Curr Biol. 8: 96-108. PMID: 9427644
10. Characterization of a human RPD3 ortholog, HDAC3.  |  Emiliani, S., et al. 1998. Proc Natl Acad Sci U S A. 95: 2795-800. PMID: 9501169
11. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes.  |  Utley, RT., et al. 1998. Nature. 394: 498-502. PMID: 9697775
12. Roles of histone acetyltransferases and deacetylases in gene regulation.  |  Kuo, MH. and Allis, CD. 1998. Bioessays. 20: 615-26. PMID: 9780836

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 4 (HDAC4) Antibody (A-4) has 50 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 4 (HDAC4) Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 4 (HDAC4) Antibody (A-4) Specifications

Alternate Product Name: HDAC4

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 530-631

Epitope Target: HDAC4

Epitope Species: mouse

Product Reactivity/Detection: HDAC4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 50 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 4 (HDAC4) Antibody (A-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent