Histone Deacetylase 2 (HDAC2) Antibody (C-8): sc-9959

HDAC2 Antibody (C-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects HDAC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry (IHC). HDAC2 (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. HDAC2 plays a crucial role in the regulation of gene expression through function as a histone deacetylase, which removes acetyl groups from lysine residues on histones, leading to chromatin condensation and transcriptional repression. This process is vital for maintaining cellular homeostasis and regulating developmental processes, as aberrant HDAC activity has been implicated in various diseases, including cancer. HDAC2 interaction with specific transcription factors and other regulatory proteins further underscores importance in epigenetic control of gene expression. Understanding HDAC2 dynamics and interactions can provide insights into therapeutic strategies for diseases characterized by dysregulated gene expression.

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Histone Deacetylase 2 (HDAC2) Antibody (C-8) References:

1. HDAC2-mediated proliferation of trophoblast cells requires the miR-183/FOXA1/IL-8 signaling pathway.  |  Zhu, H. and Wang, C. 2021. J Cell Physiol. 236: 2544-2558. PMID: 33164209
2. HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity.  |  Zhang, J., et al. 2022. J Neurosci. 42: 8918-8935. PMID: 36257688
3. HDAC2 exacerbates rheumatoid arthritis progression via the IL-17-CCL7 signaling pathway.  |  Mao, D., et al. 2023. Environ Toxicol. 38: 1743-1755. PMID: 37021908
4. Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer.  |  Guan, X., et al. 2024. Clin Transl Med. 14: e1692. PMID: 38804602
5. Nucleosome structural changes due to acetylation.  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
6. A positive role for histone acetylation in transcription factor access to nucleosomal DNA.  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
7. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
8. Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.  |  Brownell, JE., et al. 1996. Cell. 84: 843-51. PMID: 8601308
9. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.  |  Taunton, J., et al. 1996. Science. 272: 408-11. PMID: 8602529
10. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.  |  Yang, XJ., et al. 1996. Nature. 382: 319-24. PMID: 8684459
11. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.  |  Yang, WM., et al. 1996. Proc Natl Acad Sci U S A. 93: 12845-50. PMID: 8917507
12. Identification of mouse histone deacetylase 1 as a growth factor-inducible gene.  |  Bartl, S., et al. 1997. Mol Cell Biol. 17: 5033-43. PMID: 9271381

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 2 (HDAC2) Antibody (C-8) has 91 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 2 (HDAC2) Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 2 (HDAC2) Antibody (C-8) Specifications

Alternate Product Name: HDAC2

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 435-488

Epitope Target: HDAC2

Epitope Species: human

Product Reactivity/Detection: HDAC2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 91 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 2 (HDAC2) Antibody (C-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent