GSK3 alpha/beta Antibody (1H8): sc-56913
- GSK3 alpha/beta Antibody (1H8) is a mouse monoclonal IgG2a κ, cited in 21 publications, provided at 200 µg/ml
- raised against recombinant GSK-3α/β of Xenopus laevis origin
- recommended for detection of GSK-3α and GSK-3β of mouse, rat, human and Xenopus laevis origin by WB and IP
- See GSK3 alpha/beta (0011-A): sc-7291 for GSK3 alpha/beta antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GSK3 alpha/beta Antibody (1H8) for WB applications. These reagents are now offered in bundles with GSK3 alpha/beta Antibody (1H8) (see ordering information below).
GSK-3α/β Antibody (1H8) is a mouse monoclonal IgG2a antibody that detects glycogen synthase kinase 3 (GSK-3) in mouse, rat, human, and Xenopus laevis by western blotting (WB) and immunoprecipitation (IP). GSK-3 is a serine/threonine, proline-directed kinase that plays a crucial role in various signaling pathways, including those involved in glycogen synthesis and cellular adhesion, and has been linked to the pathogenesis of Alzheimer′s disease. Notably, GSK-3 exists in two isoforms, GSK-3α and GSK-3β, which differ in their subcellular localization and functional roles. GSK-3 is primarily located in the cytoplasm but can translocate to the nucleus, where GSK-3 influences gene expression and cellular responses. This localization allows GSK-3 to modulate various cellular processes, including cell cycle regulation and apoptosis, thereby impacting overall cellular health and function. Dysregulation of GSK-3 activity has been implicated in several diseases, including neurodegenerative disorders, making GSK-3 a critical target for therapeutic intervention. GSK-3 also phosphorylates Tau, a microtubule-binding protein, leading to Tau hyperphosphorylation and the formation of paired helical filaments, a hallmark of Alzheimer′s disease pathology. Anti-GSK-3α/β antibody (1H8) is an essential tool for researchers investigating the complex roles of GSK-3 in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK3 alpha/beta Antibody (1H8) | sc-56913 | 200 µg/ml | $322.00 | |||
GSK3 alpha/beta Antibody (1H8): m-IgG Fc BP-HRP Bundle | sc-537127 | 200 µg Ab; 10 µg BP | $361.00 | |||
GSK3 alpha/beta Antibody (1H8): m-IgGκ BP-HRP Bundle | sc-534319 | 200 µg Ab; 40 µg BP | $361.00 |