Anti-GSK-3α/β Antibody (0011-A) is a mouse monoclonal IgG2a κ GSK-3α/β antibody, cited in 230 publications, provided at 200 µg/ml
raised against amino acids 1-420 representing full length glycogen synthase kinase-3 beta of Xenopus laevis origin
Anti-GSK-3 alpha / beta Antibody (0011-A) is recommended for detection of GSK-3α and GSK-3β of mouse, rat, human, canine and Xenopus origin by WB, IP, IF, IHC(P) and FCM
Anti-GSK-3 alpha / beta Antibody (0011-A) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of GSK-3α/β (0011-A): sc-7291.
m-IgGκ BP-HRP is the preferred secondary detection reagent for GSK-3α/β Antibody (0011-A) for WB and IHC(P) applications. This reagent is now offered in a bundle with GSK-3α/β Antibody (0011-A) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
GSK-3α/β Antibody (0011-A) is a high quality monoclonal GSK-3 alpha / beta antibody (also designated GSK3B antibody, glycogen synthase kinase 3 antibody or GSK3 antibody) suitable for the detection of the GSK-3 alpha / beta protein of mouse, rat, human, canine and Xenopus origin. GSK-3α/β Antibody (0011-A) is available as both the non-conjugated anti-GSK-3 alpha / beta antibody form, as well as multiple conjugated forms of anti-GSK-3 alpha / beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer′s disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer′s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer′s disease.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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