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GSDMDC1 Antibody (64-Y) - Western Blotting - Image 33516
GSDMDC1 Antibody (64-Y): sc-81868. Western blot analysis of GSDMDC1 expression in Jurkat whole cell lysate.
GSDMDC1 Antibody (64-Y): sc-81868. Western blot analysis of GSDMDC1 expression in Jurkat whole cell lysate.

GSDMDC1 Antibody (64-Y): sc-81868

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Datasheets
  • GSDMDC1 Antibody (64-Y) is a mouse monoclonal IgG1 κ GSDMDC1 antibody, cited in 53 publications, provided at 100 µg/ml
  • raised against recombinant GSDMDC1 of human origin
  • recommended for detection of GSDMDC1 of human origin by WB, IP, IF, IHC(P) and ELISA
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GSDMDC1 Antibody (64-Y) for WB and IHC(P) applications. These reagents are now offered in bundles with GSDMDC1 Antibody (64-Y) (see ordering information below).
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SEE ALSO...

gasdermin Antibodies

GSDMDC1 Antibody (64-Y) is a mouse monoclonal IgG1 kappa light chain antibody that detects GSDMDC1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-GSDMDC1 antibody (64-Y) is available as non-conjugated format. GSDMDC1, consisting of 484 amino acids, plays a crucial role in regulating cell death and inflammation, which is vital for maintaining tissue homeostasis and responding to cellular stress. GSDMDC1 function is particularly important in various diseases, including cancer, where dysregulation of cell death pathways can lead to tumor progression and resistance to therapy. GSDMDC1 gene is located on human chromosome 8, a region implicated in several genetic disorders and malignancies. Notably, alterations in chromosome 8, such as translocations and amplifications, are often associated with poor prognoses in leukemias and lymphomas. Understanding GSDMDC1′s role in these processes can provide insights into potential therapeutic targets and biomarkers for disease progression.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

GSDMDC1 Antibody (64-Y) References:

  1. Chromosomes 8 and 10 workshop.  |  Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
  2. Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced.  |  Kashino, G., et al. 2001. Biochem Biophys Res Commun. 289: 111-5. PMID: 11708785
  3. Cytogenetic mapping of a novel locus for type II Waardenburg syndrome.  |  Selicorni, A., et al. 2002. Hum Genet. 110: 64-7. PMID: 11810298
  4. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.  |  McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
  5. DNA sequence and analysis of human chromosome 8.  |  Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
  6. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.  |  Agrelo, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 8822-7. PMID: 16723399
  7. Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis.  |  Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

GSDMDC1 Antibody (64-Y)

sc-81868
100 µg/ml
$322.00

GSDMDC1 Antibody (64-Y): m-IgG Fc BP-HRP Bundle

sc-537263
100 µg Ab; 10 µg BP
$361.00

GSDMDC1 Antibody (64-Y): m-IgGκ BP-HRP Bundle

sc-534492
100 µg Ab; 40 µg BP
$361.00

GSDMDC1 Antibody (64-Y): m-IgG1 BP-HRP Bundle

sc-545115
100 µg Ab; 20 µg BP
$361.00

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2025-07-17

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2025-07-17

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2025-07-17

Blocking should be done either in 5%BSA or 5%non-fat milk.please suggest

Asked by: ras21
Thank you for your question. This antibody has been established with UltraCruz® Blocking Reagent: sc-516214. The optimal blocking reagent is also dependent on the type of sample that is being analyzed. If you encounter unspecific signals, you should use a buffer based on milk-powder or switch to a BSA buffer if your signals are too weak and being overblocked.
Answered by: Tech Support Europe
Date published: 2021-02-09

Does this antibody recognize the cleaved band?

Asked by: ZAQ1
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2021-01-27

if the antibody will detect the gasdeminD N-terminal fragment?

Asked by: Tang tang
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2023-07-04

I have the same question as Tang Tang : Does the GSDMDC1 Antibody (64-Y): sc-81868 detect the human gasdemin D N-terminal fragment ?? Thank you.

Asked by: MariL
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2019-01-14

I would like to ask abput free sample of GSDMD antibody.

Asked by: MartaZ
Thank you for your question. If you have an interest in testing a free 10 µg sample of GSDMDC1 (64-Y): sc-81868 please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-26
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Rated 5 out of 5 by from its effect is goodwhen i was master, i used it to do some experiments,and my work get the nod of my teacher. and I graduated and published a good article
Date published: 2023-03-13
Rated 4 out of 5 by from WORKS!!Thx for the sample, it's works in THP-1 lysate and SN, but i really want its can get the P30 signal in WB..
Date published: 2017-12-27
Rated 3 out of 5 by from It is a good antibodyThanks for the free 10 µg sample from the company, but in my study and my vascular endothelial cell, the dilution 1:500 was used, the graph is not good, I need more study.
Date published: 2017-09-21
Rated 3 out of 5 by from Works... but low specificity for a mAbI'm sure that this antibody is good for validating transfections or something along those lines (though one could just tag a transfected protein)... for cells (e.g. THP1 monocytes) that don't seem to express as much GSDMD, this antibody has pretty high background in my hands. Though the strongest band is 52 kDa, there are lots of other bands of lesser but still quite visible intensity (these do not correspond to caspase-cleaved GSDMD, either). Picture attached to show what I mean.
Date published: 2017-07-14
Rated 5 out of 5 by from good for WB and IFI used this antibody for immunofluorescence (1:300) and WB(1:800), and I got very good and clean results for both application.
Date published: 2017-05-24
Rated 4 out of 5 by from Great Ab!Works well for western blotting on THP1 cell lysates.
Date published: 2017-03-29
Rated 5 out of 5 by from great GSDMDC1 detectionWorks well with paraffin-embedded sections for IHC. Great for human GSDMDC1 detection.
Date published: 2017-01-12
Rated 5 out of 5 by from tumor samplesWorked well for western blot with tumor samples,Good signal in western blot using 1:1000.
Date published: 2016-12-17
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GSDMDC1 Antibody (64-Y) is rated 4.2 out of 5 by 12.
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