GS2-like Antibody (G-1): sc-376365
- GS2-like Antibody (G-1) is a mouse monoclonal IgG1 κ GS2-like antibody provided at 200 µg/ml
- raised against amino acids 28-103 mapping within an internal region of GS2-like of human origin
- GS2-like Antibody (G-1) is recommended for detection of GS2-like of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-GS2-like Antibody (G-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of GS2-like (G-1): sc-376365.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GS2-like Antibody (G-1) for WB and IHC(P) applications. These reagents are now offered in bundles with GS2-like Antibody (G-1) (see ordering information below).
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GS2-like Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects GS2-like protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). GS2-like (G-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GS2-like protein, also known as patatin-like phospholipase domain containing 5 (PNPLA5), plays a crucial role in lipid metabolism and is involved in the regulation of triglyceride levels within cells. PNPLA5 is primarily expressed in adipose tissue, where PNPLA5 may significantly contribute to lipolysis, the process of breaking down fats for energy. This function is particularly important in the context of metabolic disorders, as the regulation of lipid storage and mobilization is vital for maintaining energy homeostasis. Additionally, PNPLA5 is strongly induced in the liver of ob/ob mice, highlighting PNPLA5′s potential role in obesity-related metabolic pathways. PNPLA5 expression is regulated similarly to that of adiponutrin (ADPN), although PNPLA5 mRNA levels are lower, suggesting a nuanced role in lipid metabolism that warrants further investigation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GS2-like Antibody (G-1) References:
- Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage. | Baulande, S., et al. 2001. J Biol Chem. 276: 33336-44. PMID: 11431482
- Adiponutrin: A new gene regulated by energy balance in human adipose tissue. | Liu, YM., et al. 2004. J Clin Endocrinol Metab. 89: 2684-9. PMID: 15181042
- Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. | Jenkins, CM., et al. 2004. J Biol Chem. 279: 48968-75. PMID: 15364929
- Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase. | Gao, J. and Simon, M. 2005. J Invest Dermatol. 124: 1259-66. PMID: 15955102
- Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members. | Lake, AC., et al. 2005. J Lipid Res. 46: 2477-87. PMID: 16150821
- Characterization of the human patatin-like phospholipase family. | Wilson, PA., et al. 2006. J Lipid Res. 47: 1940-9. PMID: 16799181
- Isolation of a new gene GS2 (DXS1283E) from a CpG island between STS and KAL1 on Xp22.3. | Lee, WC., et al. 1994. Genomics. 22: 372-6. PMID: 7806223
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GS2-like Antibody (G-1) | sc-376365 | 200 µg/ml | $316.00 | |||
GS2-like Antibody (G-1): m-IgG Fc BP-HRP Bundle | sc-529858 | 200 µg Ab; 10 µg BP | $354.00 | |||
GS2-like Antibody (G-1): m-IgGκ BP-HRP Bundle | sc-522928 | 200 µg Ab, 40 µg BP | $354.00 | |||
GS2-like Antibody (G-1): m-IgG1 BP-HRP Bundle | sc-543728 | 200 µg Ab; 20 µg BP | $354.00 | |||
GS2-like Antibody (G-1) AC | sc-376365 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GS2-like Antibody (G-1) HRP | sc-376365 HRP | 200 µg/ml | $316.00 | |||
GS2-like Antibody (G-1) FITC | sc-376365 FITC | 200 µg/ml | $330.00 | |||
GS2-like Antibody (G-1) PE | sc-376365 PE | 200 µg/ml | $343.00 | |||
GS2-like Antibody (G-1) Alexa Fluor® 488 | sc-376365 AF488 | 200 µg/ml | $357.00 | |||
GS2-like Antibody (G-1) Alexa Fluor® 546 | sc-376365 AF546 | 200 µg/ml | $357.00 | |||
GS2-like Antibody (G-1) Alexa Fluor® 594 | sc-376365 AF594 | 200 µg/ml | $357.00 | |||
GS2-like Antibody (G-1) Alexa Fluor® 647 | sc-376365 AF647 | 200 µg/ml | $357.00 | |||
GS2-like Antibody (G-1) Alexa Fluor® 680 | sc-376365 AF680 | 200 µg/ml | $357.00 | |||
GS2-like Antibody (G-1) Alexa Fluor® 790 | sc-376365 AF790 | 200 µg/ml | $357.00 |