group V PLA₂ Antibody (2A5): sc-20024

Group V PLA2 Antibody (2A5) is a mouse monoclonal IgG1 antibody that detects group V phospholipase A2 in human samples through immunofluorescence (IF) applications. Anti-group V phospholipase A2 antibody (2A5) recognizes a critical enzyme involved in the hydrolysis of glycerophospholipids, specifically targeting the sn-2-acyl ester bond, which leads to the release of free fatty acids, including arachidonic acid. This process is vital as arachidonic acid serves as a precursor for the synthesis of various eicosanoids, such as prostaglandins and leukotrienes, which play significant roles in mediating inflammatory responses and other physiological processes. Group V phospholipase A2 presence in macrophages highlights its importance in immune responses, as group V phospholipase A2 contributes to the generation of inflammatory mediators that can influence both local and systemic inflammation. Group V PLA2 (2A5) monoclonal antibody serves as an essential tool for researchers studying the mechanisms of inflammation and the role of phospholipases in cellular signaling pathways, providing insights into potential therapeutic targets for inflammatory diseases.

The preferred group V PLA₂ antibody is group V PLA₂ Antibody (C-4): sc-393606.