GRK 6 Antibody (XX-4): sc-100380
- GRK 6 Antibody (XX-4) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 100 µg/ml
- raised against recombinant GRK 6 of human origin
- recommended for detection of GRK 6 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GRK 6 Antibody (XX-4). This work is in progress.
GRK 6 Antibody (XX-4) is a mouse monoclonal IgG2a antibody that detects GRK 6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). GRK 6, a member of the G protein-coupled receptor kinase family, plays a crucial role in the regulation of G protein-coupled receptor signaling by phosphorylating activated receptors, which leads to their desensitization and internalization. This process is vital for maintaining cellular responsiveness to external signals, as it prevents overstimulation and allows for the fine-tuning of physiological responses. The importance of GRK 6 is underscored by its involvement in various physiological processes, including cardiovascular function and neuronal signaling, and its potential implications in diseases such as heart failure and neurodegenerative disorders. Anti-GRK 6 antibody (XX-4) is an essential tool for researchers aiming to explore the dynamics of G protein signaling pathways and the regulatory mechanisms that govern receptor activity.
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GRK 6 Antibody (XX-4) References:
- GRK6 phosphorylates IκBα at Ser(32)/Ser(36) and enhances TNF-α-induced inflammation. | Ohba, Y., et al. 2015. Biochem Biophys Res Commun. 461: 307-13. PMID: 25881508
- Aberrant GRK6 promoter methylation is associated with poor prognosis in hypopharyngeal squamous cell carcinoma. | Qiu, X., et al. 2016. Oncol Rep. 35: 1027-33. PMID: 26718636
- Prognostic value of decreased GRK6 expression in lung adenocarcinoma. | Yao, S., et al. 2016. J Cancer Res Clin Oncol. 142: 2541-2549. PMID: 27601164
- GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal. | Le, Q., et al. 2016. Cell Death Dis. 7: e2478. PMID: 27882944
- Overexpression of GRK6 associates with the progression and prognosis of colorectal carcinoma. | Tao, R., et al. 2018. Oncol Lett. 15: 5879-5886. PMID: 29552218
- GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. | Chen, X., et al. 2020. Blood Adv. 4: 76-86. PMID: 31899801
- GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma. | Yao, S., et al. 2021. Front Oncol. 11: 654812. PMID: 34136390
- G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. | Varney, MJ., et al. 2022. J Biol Chem. 298: 102421. PMID: 36030052
- GRK6 palmitoylation increasing its membrance translocation promotes LPS-induced inflammation by PI3K/ AKT pathway in kuppfer cells. | Tao, L., et al. 2023. Int Immunopharmacol. 117: 109933. PMID: 37012861
- Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension. | Liu, C., et al. 2023. Vascul Pharmacol. 153: 107233. PMID: 37742818
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRK 6 Antibody (XX-4) | sc-100380 | 100 µg/ml | $333.00 |