GRK 6 Antibody (D-10): sc-377494

GRK 6 Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects GRK 6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRK 6 (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GRK 6 plays a crucial role in regulating G protein-coupled receptor signaling, which is essential for numerous physiological processes, including vision, taste, and neurotransmission. Specifically, GRK 6 is involved in phosphorylating activated receptors, leading to desensitization and internalization, thereby modulating signaling response duration and intensity. This regulation maintains cellular homeostasis and prevents overstimulation of signaling pathways, which can lead to pathological conditions. GRK 6′s ability to interact with various receptor types, including those for neurotransmitters and hormones, underscores its importance in pharmacology and therapeutic interventions. Using anti-GRK 6 antibody (D-10) in research can provide insights into receptor regulation mechanisms and their implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GRK 6 Antibody (D-10) References:

1. The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.  |  Lorenz, W., et al. 1991. Proc Natl Acad Sci U S A. 88: 8715-9. PMID: 1656454
2. Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.  |  Benovic, JL., et al. 1991. J Biol Chem. 266: 14939-46. PMID: 1869533
3. Turning off the signal: desensitization of beta-adrenergic receptor function.  |  Hausdorff, WP., et al. 1990. FASEB J. 4: 2881-9. PMID: 2165947
4. The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.  |  Managò, F., et al. 2012. Sci Rep. 2: 301. PMID: 22393477
5. GRK6 expression in patients with hepatocellular carcinoma.  |  Li, YP. 2013. Asian Pac J Trop Med. 6: 220-3. PMID: 23375037
6. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.  |  Premont, RT., et al. 1994. J Biol Chem. 269: 6832-41. PMID: 8120045
7. An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.  |  Pei, G., et al. 1994. Proc Natl Acad Sci U S A. 91: 3633-6. PMID: 8170959
8. Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.  |  Inglese, J., et al. 1994. Proc Natl Acad Sci U S A. 91: 3637-41. PMID: 8170960
9. Structure and mechanism of the G protein-coupled receptor kinases.  |  Inglese, J., et al. 1993. J Biol Chem. 268: 23735-8. PMID: 8226899
10. Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.  |  Liggett, SB., et al. 1993. Proc Natl Acad Sci U S A. 90: 3665-9. PMID: 8386380
11. Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6.  |  Loudon, RP. and Benovic, JL. 1997. J Biol Chem. 272: 27422-7. PMID: 9341194
12. Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.  |  Stoffel, RH., et al. 1998. Biochemistry. 37: 16053-9. PMID: 9819198

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GRK 6 Antibody (D-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GRK 6 Antibody (D-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GRK 6 Antibody (D-10) Specifications

Alternate Product Name: GRK6

Product Clone Name: D-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 96-165

Epitope Target: GRK 6

Epitope Species: human

Product Reactivity/Detection: GRK 6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GRK 6 Antibody (D-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin