GRK 1 Antibody (D11): sc-56910
- GRK 1 Antibody (D11) is a mouse monoclonal IgG1 κ GRK 1 antibody provided at 200 µg/ml
- raised against full length human GRK1
- GRK 1 Antibody (D11) is recommended for detection of GRK 1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GRK 1 Antibody (D11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRK 1 Antibody (D11) for WB applications. These reagents are now offered in bundles with GRK 1 Antibody (D11) (see ordering information below).
GRK 1 Antibody (D11) is a mouse monoclonal IgG1 kappa light chain antibody that detects GRK 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRK 1 (D11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GRK 1, also known as rhodopsin kinase, plays a crucial role in regulating G protein-coupled receptor signaling, particularly in the phototransduction pathway of retinal photoreceptors. GRK 1 is primarily located in photoreceptor cells of the retina, where GRK 1 is essential for phosphorylation of activated rhodopsin, facilitating desensitization of the phototransduction cascade. Proper functioning of GRK 1 maintains visual sensitivity and prevents overstimulation of photoreceptors, which can lead to visual impairment. Dysregulation of GRK 1 has been implicated in various retinal diseases, highlighting GRK 1′s importance in both normal physiology and potential pathophysiology. With demonstrated effectiveness in detecting GRK 1 across multiple species and applications, anti-GRK 1 antibody (D11) serves as an invaluable tool for researchers studying G protein-coupled receptor signaling and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GRK 1 Antibody (D11) References:
- The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. | Lorenz, W., et al. 1991. Proc Natl Acad Sci U S A. 88: 8715-9. PMID: 1656454
- Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. | Benovic, JL., et al. 1991. J Biol Chem. 266: 14939-46. PMID: 1869533
- Turning off the signal: desensitization of beta-adrenergic receptor function. | Hausdorff, WP., et al. 1990. FASEB J. 4: 2881-9. PMID: 2165947
- Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. | Premont, RT., et al. 1994. J Biol Chem. 269: 6832-41. PMID: 8120045
- An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits. | Pei, G., et al. 1994. Proc Natl Acad Sci U S A. 91: 3633-6. PMID: 8170959
- Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. | Inglese, J., et al. 1994. Proc Natl Acad Sci U S A. 91: 3637-41. PMID: 8170960
- Structure and mechanism of the G protein-coupled receptor kinases. | Inglese, J., et al. 1993. J Biol Chem. 268: 23735-8. PMID: 8226899
- Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. | Liggett, SB., et al. 1993. Proc Natl Acad Sci U S A. 90: 3665-9. PMID: 8386380
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRK 1 Antibody (D11) | sc-56910 | 200 µg/ml | $322.00 | |||
GRK 1 Antibody (D11): m-IgG Fc BP-HRP Bundle | sc-528622 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRK 1 Antibody (D11): m-IgGκ BP-HRP Bundle | sc-521047 | 200 µg Ab, 40 µg BP | $361.00 | |||
GRK 1 Antibody (D11): m-IgG1 BP-HRP Bundle | sc-543034 | 200 µg Ab; 20 µg BP | $361.00 | |||
GRK 1 Antibody (D11) AC | sc-56910 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GRK 1 Antibody (D11) HRP | sc-56910 HRP | 200 µg/ml | $322.00 | |||
GRK 1 Antibody (D11) FITC | sc-56910 FITC | 200 µg/ml | $336.00 | |||
GRK 1 Antibody (D11) PE | sc-56910 PE | 200 µg/ml | $349.00 | |||
GRK 1 Antibody (D11) Alexa Fluor® 488 | sc-56910 AF488 | 200 µg/ml | $364.00 | |||
GRK 1 Antibody (D11) Alexa Fluor® 546 | sc-56910 AF546 | 200 µg/ml | $364.00 | |||
GRK 1 Antibody (D11) Alexa Fluor® 594 | sc-56910 AF594 | 200 µg/ml | $364.00 | |||
GRK 1 Antibody (D11) Alexa Fluor® 647 | sc-56910 AF647 | 200 µg/ml | $364.00 | |||
GRK 1 Antibody (D11) Alexa Fluor® 680 | sc-56910 AF680 | 200 µg/ml | $364.00 | |||
GRK 1 Antibody (D11) Alexa Fluor® 790 | sc-56910 AF790 | 200 µg/ml | $364.00 |