Grim19 Antibody (H-10): sc-514111
- Grim19 Antibody (H-10) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 14-33 near the N-terminus of Grim19 of human origin
- recommended for detection of Grim19 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Grim19 Antibody (H-10) for WB applications. These reagents are now offered in bundles with Grim19 Antibody (H-10) (see ordering information below).
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Grim19 Antibody (H-10) is a mouse monoclonal IgG1 antibody that detects Grim19 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Grim19, also known as gene associated with retinoic-interferon-induced mortality 19 protein or cell death-regulatory protein Grim-19, plays a crucial role in cellular processes by functioning as a member of the mitochondrial complex I, where Grim19 is essential for the assembly and electron transfer activity of the complex. Grim19 is vital for transferring electrons from NADH to the respiratory chain, thereby facilitating ATP production, which is critical for cellular energy metabolism. Additionally, Grim19 is involved in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway, where Grim19 induces apoptosis, highlighting Grim19′s potential as a tumor suppressor. Grim19 primarily localizes to the mitochondrion, with the ability to translocate to the nucleus upon IFN/RA treatment, underscoring Grim19′s importance in regulating both metabolic and apoptotic pathways. Given Grim19′s dual role in energy production and apoptosis, Grim19 may serve as a valuable biological marker or therapeutic target in cancer research and drug development.
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Grim19 Antibody (H-10) References:
- Downregulation of GRIM-19 promotes growth and migration of human glioma cells. | Zhang, Y., et al. 2011. Cancer Sci. 102: 1991-9. PMID: 21827581
- GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1α destabilization. | Liu, Q., et al. 2013. Carcinogenesis. 34: 1728-36. PMID: 23580587
- Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice. | Kalakonda, S., et al. 2013. Proc Natl Acad Sci U S A. 110: E4213-22. PMID: 24145455
- Expression of GW112 and GRIM-19 in colorectal cancer tissues. | Chen, H. and Wu, Q. 2015. J BUON. 20: 438-42. PMID: 26011333
- GRIM-19 expression is a potent prognostic marker in colorectal cancer. | Hao, M., et al. 2015. Hum Pathol. 46: 1815-20. PMID: 26363526
- Expression of GRIM-19 in adenomyosis and its possible role in pathogenesis. | Wang, J., et al. 2016. Fertil Steril. 105: 1093-101. PMID: 26769301
- GRIM-19 Restores Cervical Cancer Cell Senescence by Repressing hTERT Transcription. | Zhou, Y., et al. 2016. J Interferon Cytokine Res. 36: 506-15. PMID: 27142689
- Grim-19 expressed by recombinant adenovirus for esophageal neoplasm target therapy. | Song, J., et al. 2018. Mol Med Rep. 17: 6667-6674. PMID: 29488605
- Expression of GRIM-19 in unexplained recurrent spontaneous abortion and possible pathogenesis. | Yang, Y., et al. 2018. Mol Hum Reprod. 24: 366-374. PMID: 29741731
- Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. | Li, F., et al. 2018. Oncol Rep. 40: 3743-3751. PMID: 30272302
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Grim19 Antibody (H-10) | sc-514111 | 200 µg/ml | $322.00 | |||
Grim19 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-538583 | 200 µg Ab; 10 µg BP | $361.00 | |||
Grim19 Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-536224 | 200 µg Ab; 40 µg BP | $361.00 | |||
Grim19 Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-545781 | 200 µg Ab; 20 µg BP | $361.00 | |||
Grim19 (H-10) Neutralizing Peptide | sc-514111 P | 100 µg/0.5 ml | $69.00 |