gremlin-1 Antibody (C-7): sc-515877
- gremlin-1 Antibody (C-7) is a mouse monoclonal IgG2b κ gremlin-1 antibody, cited in 10 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 32-61 near the N-terminus of gremlin-1 of human origin
- gremlin-1 Antibody (C-7) is recommended for detection of gremlin-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-gremlin-1 Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for gremlin-1 Antibody (C-7) for WB applications. These reagents are now offered in bundles with gremlin-1 Antibody (C-7) (see ordering information below).
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gremlin-1 Antibody (C-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects gremlin-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-gremlin-1 antibody (C-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. gremlin-1 plays a crucial role in embryonic development as a member of the bone morphogenetic protein (BMP) antagonist family, which is essential for regulating BMP signaling pathways. This regulation is particularly important in limb development, where gremlin-1 is involved in the fibroblast growth factor 4 (FGF4) and sonic hedgehog (SHH) feedback loop, facilitating proper limb outgrowth and patterning. gremlin-1 is secreted and acts in the proximal airway epithelium during embryonic lung development, highlighting gremlin-1′s significance in both developmental biology and potential implications in various pathologies, including cancer. gremlin-1′s ability to interact with and inhibit BMP-2 and BMP-4 further underscores gremlin-1′s importance in cellular signaling and developmental processes, making gremlin-1 monoclonal antibody (C-7) a valuable tool for researchers studying these critical biological pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
gremlin-1 Antibody (C-7) References:
- Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. | Zúñiga, A., et al. 1999. Nature. 401: 598-602. PMID: 10524628
- DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain. | Topol, LZ., et al. 2000. Cytogenet Cell Genet. 89: 79-84. PMID: 10894942
- Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis. | Shi, W., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 280: L1030-9. PMID: 11290528
- [A novel neurotransmitter, DAN, mediates pain sensation in the spinal dorsal horn]. | Ohtori, S., et al. 2001. Nihon Rinsho. 59: 1698-703. PMID: 11554038
- The bone morphogenic protein antagonist gremlin regulates proximal-distal patterning of the lung. | Lu, MM., et al. 2001. Dev Dyn. 222: 667-80. PMID: 11748835
- Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells. | Hu, K., et al. 2017. Mol Med Rep. 15: 2186-2194. PMID: 28260028
- Gremlin-1 and gremlin-2 levels in polycystic ovary syndrome and their clinical correlations. | Koroglu, N., et al. 2019. Gynecol Endocrinol. 35: 604-607. PMID: 30712421
- Protective role of Gremlin-1 in myocardial function. | Müller, II., et al. 2021. Eur J Clin Invest. 51: e13539. PMID: 33729579
- Adipokine gremlin-1 promotes hepatic steatosis via upregulation of ER stress by suppressing autophagy-mediated signaling. | Choi, SW., et al. 2023. J Cell Physiol. 238: 966-975. PMID: 36890751
- Gremlin 1 is required for macrophage M2 polarization. | Mthunzi, L., et al. 2023. Am J Physiol Lung Cell Mol Physiol. 325: L270-L276. PMID: 37401390
- Gremlin-1 Level In Polycystic Ovary Syndrome And Its Clinical Correlations; A Case Control Study. | Abdelkarim, AM., et al. 2023. J Pak Med Assoc. 73(Suppl 4): S109-S113. PMID: 37482841
- The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. | Hsu, DR., et al. 1998. Mol Cell. 1: 673-83. PMID: 9660951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
gremlin-1 Antibody (C-7) | sc-515877 | 200 µg/ml | $322.00 | |||
gremlin-1 Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-525260 | 200 µg Ab, 40 µg BP | $361.00 | |||
gremlin-1 Antibody (C-7): m-IgG2b BP-HRP Bundle | sc-549221 | 200 µg Ab; 10 µg BP | $361.00 | |||
gremlin-1 Antibody (C-7) AC | sc-515877 AC | 500 µg/ml, 25% agarose | $424.00 | |||
gremlin-1 Antibody (C-7) HRP | sc-515877 HRP | 200 µg/ml | $322.00 | |||
gremlin-1 Antibody (C-7) FITC | sc-515877 FITC | 200 µg/ml | $336.00 | |||
gremlin-1 Antibody (C-7) PE | sc-515877 PE | 200 µg/ml | $349.00 | |||
gremlin-1 Antibody (C-7) Alexa Fluor® 488 | sc-515877 AF488 | 200 µg/ml | $364.00 | |||
gremlin-1 Antibody (C-7) Alexa Fluor® 546 | sc-515877 AF546 | 200 µg/ml | $364.00 | |||
gremlin-1 Antibody (C-7) Alexa Fluor® 594 | sc-515877 AF594 | 200 µg/ml | $364.00 | |||
gremlin-1 Antibody (C-7) Alexa Fluor® 647 | sc-515877 AF647 | 200 µg/ml | $364.00 | |||
gremlin-1 Antibody (C-7) Alexa Fluor® 680 | sc-515877 AF680 | 200 µg/ml | $364.00 | |||
gremlin-1 Antibody (C-7) Alexa Fluor® 790 | sc-515877 AF790 | 200 µg/ml | $364.00 |