gremlin-1 Activators
Gremlin-1 activators play a pivotal role in modulating the expression and activity of gremlin-1, a secreted antagonist of bone morphogenetic proteins (BMPs) with diverse roles in development and disease. Lithium chloride, a direct activator, inhibits GSK-3β, leading to the stabilization of β-catenin. This stabilized β-catenin translocates to the nucleus, promoting gremlin-1 transcription and subsequent activation. TGF-β1, while not a direct activator, induces gremlin-1 activation through canonical TGF-β signaling. TGF-β1 binding to its receptor triggers SMAD2/3 phosphorylation, initiating gremlin-1 transcription. Niclosamide, an indirect activator, modulates Wnt/β-catenin signaling by inhibiting it, preventing gremlin-1 degradation and promoting its stability. SB431542 activates gremlin-1 by inhibiting the TGF-β receptor ALK5, preventing gremlin-1 degradation and enhancing its stability. LY294002 activates gremlin-1 through PI3K/AKT signaling, boosting gremlin-1 transcription and translation. N-Acetylcysteine (NAC) activates gremlin-1 by modulating reactive oxygen species (ROS), stabilizing gremlin-1 and preventing its degradation.
Dorsomorphin, an indirect activator, inhibits BMP receptors, preventing gremlin-1 degradation and leading to its stabilization. Curcumin activates gremlin-1 by inhibiting the NF-κB pathway, enhancing gremlin-1 transcription and promoting activation. SB203580 activates gremlin-1 by inhibiting p38 MAPK, preventing its degradation and stabilizing the protein. U0126 activates gremlin-1 through MEK/ERK signaling, boosting gremlin-1 transcription and translation. Prostaglandin E2 (PGE2) activates gremlin-1 by modulating the EP4 receptor, enhancing gremlin-1 transcription. Thalidomide, while infamous for its historical context, activates gremlin-1 through TNF-α inhibition, preventing gremlin-1 degradation and promoting stability. Collectively, gremlin-1 activators showcase a diverse array of chemicals that modulate various signaling pathways, highlighting the intricate regulatory network that influences gremlin-1 expression and activity in various cellular contexts. Understanding the nuanced interactions between these activators and gremlin-1 provides insights into the dynamic regulation of BMP signaling and its implications in both development and pathological conditions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride activates gremlin-1 by inhibiting GSK-3β. GSK-3β inhibition leads to stabilization of β-catenin, which translocates to the nucleus, promoting gremlin-1 transcription and subsequent activation. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide activates gremlin-1 by inhibiting Wnt/β-catenin signaling. Wnt/β-catenin inhibition prevents gremlin-1 degradation, enhancing its stability and promoting activation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 activates gremlin-1 by inhibiting the TGF-β receptor ALK5. ALK5 inhibition prevents gremlin-1 degradation, leading to its stabilization and subsequent activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 activates gremlin-1 through PI3K/AKT signaling. PI3K/AKT activation enhances gremlin-1 transcription and translation, leading to increased expression and activation. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine activates gremlin-1 by modulating reactive oxygen species (ROS). ROS reduction stabilizes gremlin-1, preventing its degradation and promoting activation. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
Dorsomorphin activates gremlin-1 by inhibiting BMP receptors. BMP receptor inhibition prevents gremlin-1 degradation, leading to its stabilization and activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates gremlin-1 by inhibiting the NF-κB pathway. NF-κB inhibition enhances gremlin-1 transcription, leading to increased expression and activation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 activates gremlin-1 by inhibiting p38 MAPK. p38 MAPK inhibition prevents gremlin-1 degradation, leading to its stabilization and activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 activates gremlin-1 by modulating the EP4 receptor. EP4 receptor activation enhances gremlin-1 transcription, leading to increased expression and activation. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide activates gremlin-1 through inhibition of TNF-α. TNF-α inhibition prevents gremlin-1 degradation, leading to its stabilization and subsequent activation. | ||||||