gp91phox/CYBB/NOX2 Antibody (CL5): sc-130549

gp91-phox Antibody (CL5) is a mouse monoclonal IgG1 antibody that detects gp91-phox in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. gp91-phox, a critical component of the NADPH oxidase complex, plays a vital role in generating reactive oxygen species, which are essential for various cellular processes, including host defense and signaling pathways. gp91-phox is primarily located in the plasma membrane of phagocytes, such as neutrophils and eosinophils, where gp91-phox functions as a surface oxygen sensor that triggers cellular responses to hypoxia. Proper localization of gp91-phox is crucial, as gp91-phox allows for rapid generation of superoxide in response to inflammatory stimuli, thereby facilitating immune response. gp91-phox interacts with other cytosolic proteins, such as p47-phox and p67-phox, which are necessary for assembly and activation of the NADPH oxidase complex. Unique expression patterns of gp91-phox in immune cells and upregulation in vascular smooth muscle cells under certain conditions highlight gp91-phox importance in both innate immunity and vascular biology. anti-gp91-phox antibody (CL5) serves as an invaluable tool for researchers studying oxidative stress, inflammation, and related signaling pathways.

The preferred gp91phox/CYBB/NOX2 antibody is gp91phox/CYBB/NOX2 Antibody (54.1): sc-130543.