gp91-phox Activators
Common gp91-phox Activators include, but are not limited to PMA CAS 16561-29-8, Arachidonic Acid (20:4, n-6) CAS 506-32-1, Forskolin CAS 66575-29-9, Ionomycin free acid CAS 56092-81-0 and Genistein CAS 446-72-0.
gp91-phox Activators are signaling molecules or enzyme modulators that can indirectly instigate the assembly or activation of the NADPH oxidase complex. Substances like Phorbol 12-myristate 13-acetate (PMA) and Arachidonic Acid primarily target protein kinases and lipid signaling pathways, respectively, which subsequently promote the phosphorylation or translocation of NADPH oxidase subunits. The cAMP-elevating Forskolin, on the other hand, operates via cAMP-dependent protein kinase (PKA), while Ionomycin acts by elevating intracellular calcium levels. These chemicals essentially converge on influencing the interactions among the NADPH oxidase components, facilitating the active complex's assembly.
It's crucial to note that while these chemicals do not directly activate gp91-phox, their roles in cellular signaling can cause significant changes in the activity of this protein. For instance, Genistein and Sodium Vanadate act as kinase and phosphatase inhibitors, respectively, thereby altering the phosphorylation landscape crucial for NADPH oxidase activation. Nifedipine and Calmodulin modulate calcium-dependent processes, significantly affecting the cytosolic components' migration to the membrane to interact with gp91-phox.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates Protein Kinase C, which phosphorylates p47phox, a component that associates with gp91-phox. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Induces lipid signaling that can lead to activation of gp91-phox via PLC and PKC pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, modulating PKA that can indirectly interact with NADPH oxidase components. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Calcium ionophore that increases intracellular Ca2+, promoting association of cytosolic and membrane components. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Inhibits tyrosine kinases, thus affecting pathways that can modify gp91-phox activity. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Binds to p47phox, promoting its migration to the membrane and interaction with gp91-phox. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Blocks calcium channels and thereby modifies calcium-dependent regulation of gp91-phox. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits phosphatases, thus maintaining the phosphorylation status of complex components. | ||||||
Sodium metavanadate | 13718-26-8 | sc-251034 sc-251034A | 5 g 25 g | $32.00 $84.00 | 3 | |
Inhibits tyrosine phosphatases, which can influence gp91-phox activation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
A cAMP analog that activates PKA, leading to indirect modulation of NADPH oxidase assembly. | ||||||