GM-CSFRα Antibody (8D10): sc-21762

GM-CSFRα Antibody (8D10) is a mouse monoclonal IgG1 antibody that detects GM-CSFRα in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). GM-CSFRα, or Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha, plays a crucial role in hematopoiesis by mediating the effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), which is essential for the proliferation, differentiation, and survival of myeloid progenitor cells. GM-CSFRα is primarily located on the surface of hematopoietic cells, where GM-CSFRα forms a functional receptor complex with the common β subunit, facilitating high-affinity binding of GM-CSF. This interaction is vital for the activation of downstream signaling pathways that promote immune responses and inflammation. GM-CSFRα undergoes post-translational modifications, including glycosylation, which can influence stability, receptor activity, and interaction with other signaling molecules. Anti-GM-CSFRα antibody (8D10) serves as an invaluable tool for researchers studying the mechanisms of immune regulation and the role of GM-CSF in various diseases, including cancer and autoimmune disorders.

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GM-CSFRα Antibody (8D10) References:

1. The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions.  |  Krieger, M., et al. 2012. Sci Rep. 2: 697. PMID: 23019518
2. STAT3-activated GM-CSFRα translocates to the nucleus and protects CLL cells from apoptosis.  |  Li, P., et al. 2014. Mol Cancer Res. 12: 1267-82. PMID: 24836891
3. Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis.  |  Greven, DE., et al. 2015. Ann Rheum Dis. 74: 1924-30. PMID: 24936585
4. GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential.  |  Hamilton, JA. 2015. Expert Rev Clin Immunol. 11: 457-65. PMID: 25748625
5. Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation.  |  Cook, AD., et al. 2016. Arthritis Res Ther. 18: 287. PMID: 27908288
6. Neutrophil GM-CSF receptor dynamics in acute lung injury.  |  De Alessandris, S., et al. 2019. J Leukoc Biol. 105: 1183-1194. PMID: 30942918
7. Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain.  |  van Helvoort, EM., et al. 2020. Rheumatology (Oxford). 59: 3452-3457. PMID: 32365364
8. Dense GM-CSFRα-expressing immune infiltration is allied with longer survival of intrahepatic cholangiocarcinoma patients.  |  Saranaruk, P., et al. 2023. PeerJ. 11: e14883. PMID: 36883059
9. GM-CSF Promotes the Survival of Peripheral-Derived Myeloid Cells in the Central Nervous System for Pain-Induced Relapse of Neuroinflammation.  |  Matsuyama, S., et al. 2023. J Immunol. 211: 34-42. PMID: 37212607
10. Renal denervation achieves its antiarrhythmic effect through attenuating macrophage activation and neuroinflammation in stellate ganglia in chronic heart failure.  |  Hu, W., et al. 2024. Cardiovasc Res.. PMID: 39321201

The preferred GM-CSFRα antibody is GM-CSFRα Antibody (S-50): sc-456.