glypican-3 Antibody (H-10): sc-377266
- glypican-3 Antibody (H-10) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 303-464 of glypican-3 of human origin
- recommended for detection of glypican-3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- See glypican-3 (F-3): sc-390587 for glypican-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for glypican-3 Antibody (H-10) for WB applications. These reagents are now offered in bundles with glypican-3 Antibody (H-10) (see ordering information below).
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SEE ALSO...
Glypican-3 Antibody (H-10) is a mouse monoclonal IgG2a antibody that detects glypican-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Glypican-3 is an integral membrane protein that plays a crucial role in regulating tissue and organ growth, primarily through interactions with growth factors like insulin-like growth factor II (IGF-II) and fibroblast growth factor 2 (FGF-2). This regulation is vital for normal development, as dysregulation of glypican-3 can lead to conditions such as Simpson-Golabi-Behmel syndrome, which is characterized by significant pre- and post-natal overgrowth. Glypican-3 is anchored to the cell membrane via a glycosyl-phosphatidyl-inositol (GPI) anchor and is predominantly expressed in embryonic mesodermal tissues, including the lung, liver, and kidney. Understanding glypican-3 function is essential, as downregulation through mechanisms such as promoter hypermethylation or repression of specific transcription factors can have profound implications for growth regulation and developmental processes. Anti-glypican-3 antibody (H-10) is an invaluable tool for researchers investigating this protein′s role in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
glypican-3 Antibody (H-10) | sc-377266 | 200 µg/ml | $316.00 | |||
glypican-3 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-538031 | 200 µg Ab; 10 µg BP | $354.00 | |||
glypican-3 Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-535553 | 200 µg Ab; 40 µg BP | $354.00 |