GLP-1R Antibody (B-11): sc-390773
- GLP-1R Antibody (B-11) is a mouse monoclonal IgG2b κ, cited in 13 publications, provided at 200 µg/ml
- raised against amino acids 91-145 mapping within an N-terminal extracellular domain of GLP-1R of human origin
- Anti-GLP-1R Antibody (B-11) is recommended for detection of GLP-1R of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GLP-1R Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GLP-1R Antibody (B-11) for WB applications. These reagents are now offered in bundles with GLP-1R Antibody (B-11) (see ordering information below).
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GLP-1R Antibody (B-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects GLP-1R in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GLP-1R (B-11) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GLP-1R plays a crucial role in glucose metabolism and appetite regulation, primarily functioning as a receptor for glucagon-like peptide-1 (GLP-1), which is secreted in response to food intake. Upon binding of GLP-1 to GLP-1R, a cascade of intracellular signaling events triggers enhanced insulin secretion from pancreatic beta cells, reduced glucagon release, and increased satiety, making GLP-1R a vital target for diabetes treatment and obesity management. GLP-1R expression is predominantly found in the pancreas, brain, and gastrointestinal tract, highlighting GLP-1R′s importance in both metabolic and central nervous system functions. Anti-GLP-1R antibody (B-11) enables researchers to gain insights into the physiological and pathological roles of GLP-1R, furthering the understanding of GLP-1R′s potential as a therapeutic target in metabolic disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GLP-1R Antibody (B-11) References:
- Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis. | Boland, ML., et al. 2020. Nat Metab. 2: 413-431. PMID: 32478287
- Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. | Zhang, X., et al. 2020. Mol Cell. 80: 485-500.e7. PMID: 33027691
- GLP-1 regulates exercise endurance and skeletal muscle remodeling via GLP-1R/AMPK pathway. | Wu, L., et al. 2022. Biochim Biophys Acta Mol Cell Res. 1869: 119300. PMID: 35636559
- Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP. | Wang, L. 2022. Drug Des Devel Ther. 16: 1547-1559. PMID: 35651477
- Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation. | Wong, CK., et al. 2022. Cell Metab. 34: 1514-1531.e7. PMID: 36027914
- BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy. | Zimmermann, T., et al. 2022. Mol Metab. 66: 101633. PMID: 36356832
- Structural analysis of the dual agonism at GLP-1R and GCGR. | Li, Y., et al. 2023. Proc Natl Acad Sci U S A. 120: e2303696120. PMID: 37549266
- GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications. | Campbell, JE., et al. 2023. Cell Metab. 35: 1519-1529. PMID: 37591245
- Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway. | Wang, ZJ., et al. 2023. Neuropharmacology. 240: 109716. PMID: 37730113
- The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines. | Douros, JD., et al. 2024. J Endocrinol. 261: PMID: 38451873
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GLP-1R Antibody (B-11) | sc-390773 | 200 µg/ml | $316.00 | |||
GLP-1R Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-523676 | 200 µg Ab, 40 µg BP | $354.00 | |||
GLP-1R Antibody (B-11): m-IgG2b BP-HRP Bundle | sc-549132 | 200 µg Ab; 10 µg BP | $354.00 | |||
GLP-1R Antibody (B-11) AC | sc-390773 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GLP-1R Antibody (B-11) HRP | sc-390773 HRP | 200 µg/ml | $316.00 | |||
GLP-1R Antibody (B-11) FITC | sc-390773 FITC | 200 µg/ml | $330.00 | |||
GLP-1R Antibody (B-11) PE | sc-390773 PE | 200 µg/ml | $343.00 | |||
GLP-1R Antibody (B-11) Alexa Fluor® 488 | sc-390773 AF488 | 200 µg/ml | $357.00 | |||
GLP-1R Antibody (B-11) Alexa Fluor® 546 | sc-390773 AF546 | 200 µg/ml | $357.00 | |||
GLP-1R Antibody (B-11) Alexa Fluor® 594 | sc-390773 AF594 | 200 µg/ml | $357.00 | |||
GLP-1R Antibody (B-11) Alexa Fluor® 647 | sc-390773 AF647 | 200 µg/ml | $357.00 | |||
GLP-1R Antibody (B-11) Alexa Fluor® 680 | sc-390773 AF680 | 200 µg/ml | $357.00 | |||
GLP-1R Antibody (B-11) Alexa Fluor® 790 | sc-390773 AF790 | 200 µg/ml | $357.00 |