GKLF/KLF4 Antibody (B-9): sc-166100

GKLF Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects GKLF in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GKLF, or gut Kruppel-like factor, is a zinc finger transcription factor that plays a crucial role in regulating gene expression during cellular growth, differentiation, and tissue homeostasis, particularly in the gastrointestinal tract. GKLF regulates processes such as cell proliferation, apoptosis, and epithelial barrier function in maintaining intestinal epithelium integrity. Dysregulation of GKLF has been linked to gastrointestinal diseases, including colorectal cancer, inflammatory bowel diseases, and gastric pathologies, highlighting GKLF′s importance in maintaining cellular balance. GKLF exerts effects by interacting with other transcription factors and co-regulators to modulate critical signaling pathways, such as Wnt/β-catenin and TGF-β, which govern cellular growth and repair. GKLF has been shown to influence epithelial-to-mesenchymal transition (EMT), a process involved in wound healing, tissue regeneration, and cancer progression. GKLF mediates cellular adaptation to oxidative stress and DNA damage, ensuring proper recovery and survival. Anti-GKLF antibody (B-9) provides researchers with a powerful tool to investigate GKLF′s role in epithelial biology, disease pathogenesis, and molecular pathways critical to cellular homeostasis.

The preferred GKLF/KLF4 antibody is GKLF/KLF4 Antibody (B-8): sc-393462.