GIT1 Antibody (B-2): sc-373882
- GIT1 Antibody (B-2) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 7-35 near the N-terminus of GIT1 of rat origin
- recommended for detection of GIT1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GIT1 Antibody (B-2) for WB applications. These reagents are now offered in bundles with GIT1 Antibody (B-2) (see ordering information below).
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GIT1 Antibody (B-2) is a mouse monoclonal IgG2b antibody that detects GIT1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GIT1 plays a crucial role in the regulation of G protein-coupled receptor signaling, particularly in its interaction with G protein-coupled receptor kinases (GRKs), which phosphorylate and inactivate cell surface receptors, thereby modulating signal transduction pathways. GIT1 is primarily located in the cytoplasm and at the plasma membrane, where GIT1 acts as a GTPase-activating protein for members of the ADP ribosylation factor (ARF) family, which are essential for vesicular trafficking. This localization is significant because GIT1 effectively regulates the internalization and resensitization of receptors, such as the β2-adrenergic receptor, influencing cellular responses to external stimuli. Anti-GIT1 antibody (B-2) is an invaluable tool for researchers studying the dynamics of G protein signaling and its implications in various physiological and pathological processes.
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GIT1 Antibody (B-2) References:
- GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration. | Manabe, R., et al. 2002. J Cell Sci. 115: 1497-510. PMID: 11896197
- Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. | Menon, P., et al. 2010. Brain Res. 1317: 218-26. PMID: 20043896
- GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass. | Menon, P., et al. 2010. J Cell Physiol. 225: 777-85. PMID: 20568227
- GIT1 regulates synaptic structural plasticity underlying learning. | Martyn, AC., et al. 2018. PLoS One. 13: e0194350. PMID: 29554125
- Inhibiting GIT1 reduces the growth, invasion, and angiogenesis of osteosarcoma. | Zhang, Z., et al. 2018. Cancer Manag Res. 10: 6445-6455. PMID: 30555255
- Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way. | Zhao, SJ., et al. 2020. J Bone Miner Res. 35: 2015-2031. PMID: 32460388
- GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. | Wang, G., et al. 2021. Bioengineered. 12: 30-43. PMID: 33258389
- GIT1 protects traumatically injured spinal cord by prompting microvascular endothelial cells to clear myelin debris. | Wan, B., et al. 2021. Aging (Albany NY). 13: 7067-7083. PMID: 33621952
- GIT1 is an untolerized autoantigen involved in immunologic disturbance of spermatogenesis. | Nagahori, K., et al. 2022. Histochem Cell Biol. 157: 309-319. PMID: 35066604
- Low testosterone state inhibits erectile function by downregulating the expression of GIT1 in rat penile corpus cavernosum. | Gu, J., et al. 2023. Sex Med. 11: qfad017. PMID: 37256221
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GIT1 Antibody (B-2) | sc-373882 | 200 µg/ml | $322.00 | |||
GIT1 Antibody (B-2): m-IgGκ BP-HRP Bundle | sc-535325 | 200 µg Ab; 40 µg BP | $361.00 | |||
GIT1 Antibody (B-2): m-IgG2b BP-HRP Bundle | sc-549394 | 200 µg Ab; 10 µg BP | $361.00 | |||
GIT1 (B-2) Neutralizing Peptide | sc-373882 P | 100 µg/0.5 ml | $69.00 |