GFRP Antibody (A-8): sc-514199

GFRP Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects GTP cyclohydrolase I feedback regulatory protein (GFRP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GFRP plays a crucial role in the regulation of GTP cyclohydrolase I activity by mediating feedback inhibition through tetrahydrobiopterin, which is essential for maintaining the balance of neurotransmitter synthesis, particularly in the production of dopamine, serotonin, and norepinephrine. The importance of GFRP′s function is underscored by its ability to respond to L-phenylalanine, which can reverse the inhibition of GTP cyclohydrolase I, thereby enhancing enzyme activity and influencing metabolic pathways. Additionally, GFRP is typically expressed as a homodimer or pentamer, a structural characteristic that may be significant for its regulatory functions and interactions within the cell. Anti-GFRP antibody (A-8) is an invaluable tool for researchers studying the intricate mechanisms of neurotransmitter regulation and the physiological implications of GFRP in various biological contexts.

The preferred GFRP antibody is GFRP Antibody (D-11): sc-514098.