GAPT Antibody (B-6): sc-398293

GAPT Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects GAPT (growth factor receptor-bound protein 2-binding adapter protein, transmembrane) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GAPT is a 157 amino acid single-pass membrane protein belonging to the GAPT family, and GAPT plays a crucial role in the regulation of B-cell proliferation, particularly after stimulation through the B-cell receptor, which is essential for maintaining B-cell marginal zone integrity. GAPT is primarily expressed in peripheral blood lymphocytes and the spleen, with lower levels detected in the thymus, highlighting GAPT′s importance in immune system function. GAPT interacts with the GRB2 protein, which is involved in various signaling pathways, further emphasizing GAPT′s role in cellular communication and response. The GAPT gene is located on human chromosome 5q11.2, a region associated with several genetic disorders, including Cockayne syndrome and familial adenomatous polyposis, underscoring GAPT′s significance in both normal physiology and disease contexts. anti-GAPT antibody (B-6) has been validated in multiple B-cell lines, including THP-1 and TY, making anti-GAPT antibody (B-6) a reliable tool for researchers studying B-cell biology and related pathologies.

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GAPT Antibody (B-6) References:

1. Palmitoylated transmembrane adaptor proteins in leukocyte signaling.  |  Stepanek, O., et al. 2014. Cell Signal. 26: 895-902. PMID: 24440308
2. Herbal formula GAPT prevents beta amyloid deposition induced Ca(2+)/Calmodulin-dependent protein kinase II and Ca(2+)/Calmodulin-dependent protein phosphatase 2B imbalance in APPV717I mice.  |  Shi, J., et al. 2016. BMC Complement Altern Med. 16: 159. PMID: 27245225
3. Effect of GAPT extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of APPV717I transgenic mice.  |  Ni, JN., et al. 2017. Chin J Integr Med. 23: 605-610. PMID: 28634862
4. The influence of GAPT extraction on synapse loss of APPswe/PS1dE9 transgenic mice via adjusting Bcl-2/Bax balance.  |  Shi, J., et al. 2018. Alzheimers Dement (N Y). 4: 724-736. PMID: 30581978
5. Effect of Chinese herbal compound GAPT on the early brain glucose metabolism of APP/PS1 transgenic mice.  |  Mana, L., et al. 2019. Int J Immunopathol Pharmacol. 33: 2058738419841482. PMID: 30957587
6. GAPT regulates cholinergic dysfunction and oxidative stress in the brains of learning and memory impairment mice induced by scopolamine.  |  Liu, Z., et al. 2020. Brain Behav. 10: e01602. PMID: 32174034
7. Urine Extracellular Vesicle GATA2 mRNA Discriminates Biopsy Result in Men with Suspicion of Prostate Cancer.  |  Woo, J., et al. 2020. J Urol. 204: 691-700. PMID: 32250729
8. Retraction Note: Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin-dependent protein kinase II and Ca2+/Calmodulin-dependent protein phosphatase 2B imbalance in APPV717I mice.  |  Shi, J., et al. 2021. BMC Complement Med Ther. 21: 157. PMID: 34049557
9. Are 'GAPT Charges' Really Just Charges?  |  Richter, WE., et al. 2021. J Chem Inf Model. 61: 3881-3890. PMID: 34324335
10. Controlled Nanopore Sizes in Supraparticle Supports for Enhanced Propane Dehydrogenation with GaPt SCALMS Catalysts.  |  Madubuko, N., et al. 2024. ACS Appl Nano Mater. 7: 24356-24367. PMID: 39539809

The preferred GAPT antibody is GAPT Antibody (H-8): sc-398271.