GAP1-InsP₄ BP Antibody (E-7): sc-398127

GAP1-InsP4 BP Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects GAP1-InsP4 BP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GAP1-InsP4 BP, also known as Ras p21 protein activator (GTPase-activating protein) 3, is a crucial 829-amino acid protein that plays a significant role in cellular signaling by binding phospholipids in both calcium-dependent and -independent manners. GAP1-InsP4 BP is part of the Ras GTPase-activating protein family, which includes four distinct genes, and features an N-terminal tandem C2 domain, a GAP-related domain, and a C-terminal pleckstrin homology (PH) domain. The structure of GAP1-InsP4 BP is particularly important as PH domains are essential for membrane targeting, allowing GAP1-InsP4 BP to bind specific phospholipids. Upon stimulation by agonists that promote the production of phosphatidylinositol 3,4,5-trisphosphate, GAP1-InsP4 BP selectively interacts with inositol phosphates, facilitating localization to the plasma membrane. This interaction is vital for the regulation of various signaling pathways, underscoring GAP1-InsP4 BP′s importance in cellular function and communication.

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GAP1-InsP₄ BP Antibody (E-7) References:

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The preferred GAP1-InsP₄ BP antibody is GAP1-InsP₄ BP Antibody (E-9): sc-398283.