γ1-Adaptin Antibody (B-2): sc-25291

γ1-Adaptin Antibody (B-2) is a mouse monoclonal IgG2a antibody that detects γ1-Adaptin in mouse and rat samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ1-Adaptin plays a crucial role in clathrin-mediated endocytosis, which is essential for receptor internalization and membrane protein uptake, thereby regulating cellular signaling and nutrient uptake. γ1-Adaptin is primarily located at the plasma membrane and in clathrin-coated pits, where γ1-Adaptin interacts with other adaptor proteins to facilitate clathrin-coated vesicle formation. Proper functioning of γ1-Adaptin is vital for maintaining cellular homeostasis and ensuring efficient cell communication, as disruptions can lead to various diseases, including cancer and neurodegenerative disorders. anti-γ1-Adaptin antibody (B-2) serves as an invaluable tool for researchers studying endocytic pathways and their implications in health and disease, providing insights into molecular mechanisms underlying receptor trafficking and signal transduction.

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γ1-Adaptin Antibody (B-2) References:

1. Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes.  |  Deneka, M., et al. 2003. EMBO J. 22: 2645-57. PMID: 12773381
2. A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice.  |  Johnson, KR., et al. 2016. Mamm Genome. 27: 200-12. PMID: 27090238
3. AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis.  |  Tao, X., et al. 2017. Cancer Lett. 408: 33-42. PMID: 28823958
4. Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells.  |  Davaadelger, B., et al. 2018. Endocrinology. 159: 3581-3595. PMID: 30203004
5. MEG3 promotes liver cancer by activating PI3K/AKT pathway through regulating AP1G1.  |  Sun, Y., et al. 2019. Eur Rev Med Pharmacol Sci. 23: 1459-1467. PMID: 30840267
6. HCP5 promotes colon cancer development by activating AP1G1 via PI3K/AKT pathway.  |  Yun, WK., et al. 2019. Eur Rev Med Pharmacol Sci. 23: 2786-2793. PMID: 31002129
7. A Contemporary Approach to Diagnosis and Treatment of Combined Hepatocellular-Cholangiocarcinoma.  |  Raevskaya, O., et al. 2020. Curr Hepatol Rep. 19: 478-485. PMID: 33415066
8. De novo and bi-allelic variants in AP1G1 cause neurodevelopmental disorder with developmental delay, intellectual disability, and epilepsy.  |  Usmani, MA., et al. 2021. Am J Hum Genet. 108: 1330-1341. PMID: 34102099
9. Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.  |  Rebendenne, A., et al. 2022. Nat Genet. 54: 1090-1102. PMID: 35879413
10. Endosomal protein expression of γ1-adaptin is associated with tumor growth activity and relapse-free survival in breast cancer.  |  Hoshi, N., et al. 2024. Breast Cancer. 31: 305-316. PMID: 38265632

The preferred γ1-Adaptin antibody is γ1-Adaptin Antibody (F-10): sc-398867.