G-CSFR Antibody (A-7): sc-514639
- G-CSFR Antibody (A-7) is a mouse monoclonal IgG2b κ G-CSFR antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 77-99 within an N-terminal extracellular domain of G-CSFR of human origin
- G-CSFR Antibody (A-7) is recommended for detection of G-CSFR of human origin by WB, IP, IF and ELISA
- Anti-G-CSFR Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for G-CSFR Antibody (A-7) for WB applications. These reagents are now offered in bundles with G-CSFR Antibody (A-7) (see ordering information below).
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G-CSFR Antibody (A-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects G-CSFR protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-G-CSFR antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. G-CSFR plays a crucial role in hematopoiesis by mediating the effects of granulocyte colony-stimulating factor (G-CSF), which is essential for the proliferation and differentiation of neutrophil precursors in the bone marrow. This process is vital for maintaining the immune response, particularly during infections or inflammatory conditions. G-CSFR is unique among hematopoietic receptors as G-CSFR forms homodimeric complexes upon ligand binding, rather than the heteromeric complexes typical of other receptors in the cytokine/hematopoietic receptor superfamily. G-CSFR has four distinct alternative splice variants, one of which is a soluble receptor that can modulate G-CSF signaling. Understanding the structure and function of G-CSFR is important for developing therapeutic strategies targeting neutrophil-related disorders, making G-CSFR monoclonal antibody (A-7) an invaluable tool for researchers studying these pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
G-CSFR Antibody (A-7) References:
- Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival. | Hunter, MG. and Avalos, BR. 2000. Blood. 95: 2132-7. PMID: 10706885
- Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells. | Akbarzadeh, S., et al. 2002. Blood. 99: 879-87. PMID: 11806990
- Granulocyte colony-stimulating factor receptor signaling defects from neutropenia to leukemia. | Corey, SJ. and Zhu, QS. 2002. Isr Med Assoc J. 4: 1032-4. PMID: 12489499
- Granulocyte colony-stimulating factor receptor signals for beta1-integrin expression and adhesion in bladder cancer. | Chakraborty, A., et al. 2004. Urology. 63: 177-83. PMID: 14751388
- Granulocyte colony-stimulating factor/granulocyte colony-stimulating factor receptor biological axis promotes survival and growth of bladder cancer cells. | Chakraborty, A. and Guha, S. 2007. Urology. 69: 1210-5. PMID: 17572226
- Granulocyte colony-stimulating factor receptor T595I (T618I) mutation confers ligand independence and enhanced signaling. | Mehta, HM., et al. 2013. Leukemia. 27: 2407-10. PMID: 23739288
- Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer. | Kumar, J., et al. 2015. Br J Cancer. 113: 1642-3. PMID: 26625223
- Gain-of-function mutations in granulocyte colony-stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation. | Zhang, H., et al. 2018. J Biol Chem. 293: 7387-7396. PMID: 29572350
- Granulocyte colony-stimulating factor receptor at various differentiation stages of normal and leukemic hematopoietic cells. | Shinjo, K., et al. 1997. Leuk Lymphoma. 25: 37-46. PMID: 9130612
- The granulocyte colony-stimulating factor receptor and its role in disorders of granulopoiesis. | Avalos, BR. 1998. Leuk Lymphoma. 28: 265-73. PMID: 9517498
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
G-CSFR Antibody (A-7) | sc-514639 | 200 µg/ml | $322.00 | |||
G-CSFR Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-524798 | 200 µg Ab, 40 µg BP | $361.00 | |||
G-CSFR Antibody (A-7): m-IgG2b BP-HRP Bundle | sc-549185 | 200 µg Ab; 10 µg BP | $361.00 | |||
G-CSFR Antibody (A-7) AC | sc-514639 AC | 500 µg/ml, 25% agarose | $424.00 | |||
G-CSFR Antibody (A-7) HRP | sc-514639 HRP | 200 µg/ml | $322.00 | |||
G-CSFR Antibody (A-7) FITC | sc-514639 FITC | 200 µg/ml | $336.00 | |||
G-CSFR Antibody (A-7) PE | sc-514639 PE | 200 µg/ml | $349.00 | |||
G-CSFR Antibody (A-7) Alexa Fluor® 488 | sc-514639 AF488 | 200 µg/ml | $364.00 | |||
G-CSFR Antibody (A-7) Alexa Fluor® 546 | sc-514639 AF546 | 200 µg/ml | $364.00 | |||
G-CSFR Antibody (A-7) Alexa Fluor® 594 | sc-514639 AF594 | 200 µg/ml | $364.00 | |||
G-CSFR Antibody (A-7) Alexa Fluor® 647 | sc-514639 AF647 | 200 µg/ml | $364.00 | |||
G-CSFR Antibody (A-7) Alexa Fluor® 680 | sc-514639 AF680 | 200 µg/ml | $364.00 | |||
G-CSFR Antibody (A-7) Alexa Fluor® 790 | sc-514639 AF790 | 200 µg/ml | $364.00 | |||
G-CSFR (A-7) Neutralizing Peptide | sc-514639 P | 100 µg/0.5 ml | $69.00 |