fumarate hydratase Antibody (H-6): sc-393992

Fumarate hydratase Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects fumarate hydratase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-fumarate hydratase antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fumarate hydratase is a crucial mitochondrial enzyme that plays a significant role in the Krebs cycle by catalyzing the reversible hydration of fumaric acid to produce l-malic acid, a key intermediate in cellular respiration and energy production. Proper functioning of fumarate hydratase is vital, as deficiencies or mutations can lead to serious health conditions, including multiple cutaneous and uterine leiomyoma syndrome, characterized by a predisposition to renal tumors and smooth muscle tumors. Fumarate hydratase deficiency has been linked to neurological issues such as seizures, stemming from prenatal brain dysgenesis, highlighting this enzyme′s importance not only in metabolic processes but also in maintaining overall cellular health and function.

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fumarate hydratase Antibody (H-6) References:

1. Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.  |  Tyrakis, PA., et al. 2017. Cell Rep. 21: 1036-1047. PMID: 29069586
2. Integrated Molecular Characterization of Fumarate Hydratase-deficient Renal Cell Carcinoma.  |  Sun, G., et al. 2021. Clin Cancer Res. 27: 1734-1743. PMID: 33414138
3. Response to systemic therapy in fumarate hydratase-deficient renal cell carcinoma.  |  Carril-Ajuria, L., et al. 2021. Eur J Cancer. 151: 106-114. PMID: 33975058
4. Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing.  |  Lu, E., et al. 2022. Cancer. 128: 675-684. PMID: 34724198
5. Fumarate hydratase deficiency induces chronic myeloid leukemia progression.  |  Li, S., et al. 2019. Transl Cancer Res. 8: 592-602. PMID: 35116792
6. Fumarate hydratase gene germline variants and mosaicism associated with pheochromocytoma and paraganglioma.  |  Ma, X., et al. 2022. Ann N Y Acad Sci. 1516: 262-270. PMID: 35821608
7. Improving Systemic Therapy for Fumarate Hydratase-deficient Renal Cell Carcinoma.  |  Carlo, MI. 2023. Eur Urol. 83: e113-e114. PMID: 36682904
8. Fumarate Hydratase and S-(2-Succinyl)-Cysteine Immunohistochemistry Shows Evidence of Fumarate Hydratase Deficiency in 2% of Uterine Leiomyosarcomas: A Cohort Study of 348 Tumors.  |  Chapel, DB., et al. 2023. Int J Gynecol Pathol. 42: 120-135. PMID: 36729957
9. Fumarate hydratase inhibition activates innate immunity via mitochondrial nucleic acid release.  |  Li, X., et al. 2023. MedComm (2020). 4: e314. PMID: 37426680
10. Fumarate hydratase functions as a tumor suppressor in endometrial cancer by inactivating EGFR signaling.  |  Wang, YY., et al. 2023. Oncol Rep. 50: PMID: 37615251

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-fumarate hydratase Antibody (H-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-fumarate hydratase Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

fumarate hydratase Antibody (H-6) Specifications

Alternate Product Name: fumarate hydratase

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 426-510

Epitope Target: fumarate hydratase

Epitope Species: human

Product Reactivity/Detection: fumarate hydratase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for fumarate hydratase Antibody (H-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred fumarate hydratase antibody is fumarate hydratase Antibody (J-13): sc-100743.