Fra1 Antibody (F-8): sc-271657
- Fra1 Antibody (F-8) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-34 at the N-terminus of Fra-1 of rat origin
- recommended for detection of Fra-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-271657 X, 200 µg/0.1 ml)
- See Fra1 (D-3): sc-376148 for Fra1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Fra1 Antibody (F-8) for WB and IHC(P) applications. These reagents are now offered in bundles with Fra1 Antibody (F-8) (see ordering information below).
Fra-2 Antibody (G-5) is a mouse monoclonal IgG2a kappa light chain antibody raised against amino acids 180-282 of human Fra-2 (Fos-related antigen 2/FOSL2), a crucial nuclear transcription factor. Anti-Fra-2 antibody (G-5) recognizes an epitope within this region and demonstrates broad species cross-reactivity, detecting Fra-2 in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. Fra-2 maintains precise nuclear localization, where Fra-2 forms heterodimers with Jun family proteins, particularly c-Jun, through specialized leucine zipper and basic regions. These structural elements prove essential for both dimerization and DNA binding, enabling Fra-2-Jun complexes to recognize specific DNA sequences called TPA-responsive elements (TRE) within target gene promoters. Through this sophisticated mechanism, Fra-2 modulates transcriptional activity within the Activator Protein-1 (AP-1) complex, orchestrating the expression of genes controlling cell proliferation, differentiation, and apoptosis. Through these diverse cellular functions, Fra-2 (G-5) antibody provides researchers with a valuable tool for investigating transcriptional regulation and fundamental cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
Fra1 Antibody (F-8) References:
- Fra-1: a novel target for retinoid action. | Kaiser, A., et al. 1999. FEBS Lett. 448: 45-8. PMID: 10217407
- The Fos-related antigen Fra-1 is an activator of bone matrix formation. | Eferl, R., et al. 2004. EMBO J. 23: 2789-99. PMID: 15229648
- Dietary energy restriction, in part through glucocorticoid hormones, mediates the impact of 12-O-tetradecanoylphorbol-13-acetate on jun D and fra-1 in Sencar mouse epidermis. | Przybyszewski, J., et al. 2010. Mol Carcinog. 49: 592-602. PMID: 20232358
- Retinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis. | Rajabi, HN., et al. 2014. J Biol Chem. 289: 23417-27. PMID: 25006242
- Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer. | He, J., et al. 2015. Int J Oncol. 47: 1725-34. PMID: 26330014
- Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival. | Iskit, S., et al. 2015. Oncotarget. 6: 43146-61. PMID: 26646695
- PKCθ-induced phosphorylations control the ability of Fra-1 to stimulate gene expression and cancer cell migration. | Belguise, K., et al. 2017. Cancer Lett. 385: 97-107. PMID: 27816489
- Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion. | Annis, MG., et al. 2018. Breast Cancer Res. 20: 9. PMID: 29382358
- Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis. | Hannemann, N., et al. 2019. J Clin Invest. 129: 2669-2684. PMID: 30990796
- Fra-1 Inhibits Cell Growth and the Warburg Effect in Cervical Cancer Cells via STAT1 Regulation of the p53 Signaling Pathway. | Zhang, M., et al. 2020. Front Cell Dev Biol. 8: 579629. PMID: 33102485
- FRA-1: A key factor regulating signal transduction of tumor cells and a potential target molecule for tumor therapy. | Zeng, F., et al. 2022. Biomed Pharmacother. 150: 113037. PMID: 35658206
- Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron. | Bergers, G., et al. 1995. Mol Cell Biol. 15: 3748-58. PMID: 7791782
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fra1 Antibody (F-8) | sc-271657 | 200 µg/ml | $322.00 | |||
Fra1 Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-537675 | 200 µg Ab; 10 µg BP | $361.00 | |||
Fra1 Antibody (F-8): m-IgGκ BP-HRP Bundle | sc-535016 | 200 µg Ab; 40 µg BP | $361.00 | |||
Fra1 Antibody (F-8): m-IgG1 BP-HRP Bundle | sc-545299 | 200 µg Ab; 20 µg BP | $361.00 | |||
Fra1 (F-8) Neutralizing Peptide | sc-271657 P | 100 µg/0.5 ml | $69.00 | |||
Fra1 Antibody (F-8) X | sc-271657 X | 200 µg/0.1 ml | $322.00 |