FOXP2 Antibody (5C11A8): sc-517261

FOXP2 Antibody (5C11A8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Forkhead box protein P2 (FOXP2) protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FOXP2 antibody (5C11A8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FOXP2 protein is a crucial transcription factor that plays a significant role in the development of neural circuits involved in speech and language, making FOXP2 essential for effective communication in humans. Mutations in FOXP2 gene have been linked to language and speech disorders, highlighting FOXP2′s importance in cognitive development and social interaction. FOXP2 protein is primarily located in the nucleus, where FOXP2 binds to specific DNA sequences to regulate the expression of target genes, thereby influencing neuronal development and function. Understanding FOXP2′s role in the brain can provide insights into the molecular mechanisms underlying language acquisition and the evolution of human communication. FOXP2 gene is located on chromosome 7q31, and FOXP2 expression is tightly regulated during development, particularly in areas of the brain associated with language processing.

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FOXP2 Antibody (5C11A8) References:

1. The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder.  |  Lai, CS., et al. 2000. Am J Hum Genet. 67: 357-68. PMID: 10880297
2. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.  |  Bennett, CL., et al. 2001. Nat Genet. 27: 20-1. PMID: 11137993
3. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.  |  Brunkow, ME., et al. 2001. Nat Genet. 27: 68-73. PMID: 11138001
4. Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors.  |  Shu, W., et al. 2001. J Biol Chem. 276: 27488-97. PMID: 11358962
5. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation.  |  Schubert, LA., et al. 2001. J Biol Chem. 276: 37672-9. PMID: 11483607
6. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.  |  Banham, AH., et al. 2001. Cancer Res. 61: 8820-9. PMID: 11751404
7. Interaction between MAOA and FOXP2 in association with autism and verbal communication in a Korean population.  |  Park, Y., et al. 2014. J Child Neurol. 29: NP207-11. PMID: 24356376
8. Dissecting FOXP2 Oligomerization and DNA Binding.  |  Häußermann, K., et al. 2019. Angew Chem Int Ed Engl. 58: 7662-7667. PMID: 30887622
9. Downregulation of miR-222-3p Reverses Doxorubicin-Resistance in LoVo Cells Through Upregulating Forkhead Box Protein P2 (FOXP2) Protein.  |  Wang, H., et al. 2019. Med Sci Monit. 25: 2169-2178. PMID: 30904920
10. An Etiological Foxp2 Mutation Impairs Neuronal Gain in Layer VI Cortico-Thalamic Cells through Increased GABAB/GIRK Signaling.  |  Druart, M., et al. 2020. J Neurosci. 40: 8543-8555. PMID: 33020214
11. β-catenin regulates FOXP2 transcriptional activity via multiple binding sites.  |  Richter, G., et al. 2021. FEBS J. 288: 3261-3284. PMID: 33284517
12. FOXP2 overexpression upregulates LAMA4 expression and thereby alleviates preeclampsia by regulating trophoblast behavior.  |  Liu, S., et al. 2024. Commun Biol. 7: 1427. PMID: 39487340

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXP2 Antibody (5C11A8) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXP2 Antibody (5C11A8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXP2 Antibody (5C11A8) Specifications

Alternate Product Name: FOXP2

Product Clone Name: 5C11A8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 47-287

Epitope Target: FOXP2

Epitope Species: human

Product Reactivity/Detection: FOXP2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for FOXP2 Antibody (5C11A8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred FOXP2 antibody is FOXP2 Antibody (A-10): sc-518143.