FOXP2 Antibody (A-10): sc-518143
- FOXP2 Antibody (A-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 670-691 of FOXP2 of human origin
- recommended for detection of FOXP2 of human origin by WB, IP, IF and ELISA
- Anti-FOXP2 Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for FOXP2 Antibody (A-10) for WB applications. These reagents are now offered in bundles with FOXP2 Antibody (A-10) (see ordering information below).
FOXP2 Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects FOXP2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FOXP2 (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FOXP2 plays a crucial role in language development and speech, making this protein a significant focus of research in understanding the genetic basis of communication disorders. Located primarily in the brain, particularly in areas associated with language processing, FOXP2 is essential for the proper development of neural circuits involved in speech and language. Mutations in FOXP2 have been linked to speech and language deficits, highlighting FOXP2′s importance in neurodevelopmental processes. The gene encoding human FOXP2 is situated on chromosome 7q31, and FOXP2 expression is tightly regulated during development, with notable activity in the basal ganglia and other brain regions. Understanding FOXP2 function and regulation is vital for unraveling the complexities of language acquisition and the potential implications of FOXP2 dysfunction in various speech and language disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FOXP2 Antibody (A-10) References:
- Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. | Vernes, SC., et al. 2011. PLoS Genet. 7: e1002145. PMID: 21765815
- Enhanced procedural learning of speech sound categories in a genetic variant of FOXP2. | Chandrasekaran, B., et al. 2015. J Neurosci. 35: 7808-12. PMID: 25995468
- The Key Regulator for Language and Speech Development, FOXP2, is a Novel Substrate for SUMOylation. | Meredith, LJ., et al. 2016. J Cell Biochem. 117: 426-38. PMID: 26212494
- Contactin‑associated protein‑like 2 expression in SH‑SY5Y cells is upregulated by a FOXP2 mutant with a shortened poly‑glutamine tract. | Zhao, Y., et al. 2015. Mol Med Rep. 12: 8162-8. PMID: 26497390
- FOXP2 gene deletion and infant feeding difficulties: a case report. | Zimmerman, E. and Maron, JL. 2016. Cold Spring Harb Mol Case Stud. 2: a000547. PMID: 27148578
- FOXP2 variation in great ape populations offers insight into the evolution of communication skills. | Staes, N., et al. 2017. Sci Rep. 7: 16866. PMID: 29203828
- MiR-34a Regulates Axonal Growth of Dorsal Root Ganglia Neurons by Targeting FOXP2 and VAT1 in Postnatal and Adult Mouse. | Jia, L., et al. 2018. Mol Neurobiol. 55: 9089-9099. PMID: 29637443
- lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR‑18a‑5p/SOX6 signaling axis. | Zhao, Y., et al. 2021. Oncol Rep. 45: 1118-1132. PMID: 33432363
- Foxp2 Is Required for Nucleus Accumbens-mediated Multifaceted Limbic Function. | He, BH., et al. 2024. Neuroscience. 542: 33-46. PMID: 38354901
- ALKBH5 activates CEP55 transcription through m6A demethylation in FOXP2 mRNA and expedites cell cycle entry and EMT in ovarian cancer. | Yu, J., et al. 2024. Biol Direct. 19: 105. PMID: 39511642
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FOXP2 Antibody (A-10) | sc-518143 | 200 µg/ml | $322.00 | |||
FOXP2 Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-541122 | 200 µg Ab; 10 µg BP | $361.00 | |||
FOXP2 Antibody (A-10): m-IgG1 BP-HRP Bundle | sc-542597 | 200 µg Ab; 20 µg BP | $361.00 | |||
Antibody (A-10) AC | sc-518143 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Antibody (A-10) HRP | sc-518143 HRP | 200 µg/ml | $322.00 | |||
Antibody (A-10) FITC | sc-518143 FITC | 200 µg/ml | $336.00 | |||
Antibody (A-10) PE | sc-518143 PE | 200 µg/ml | $349.00 | |||
Antibody (A-10) Alexa Fluor® 488 | sc-518143 AF488 | 200 µg/ml | $364.00 | |||
Antibody (A-10) Alexa Fluor® 546 | sc-518143 AF546 | 200 µg/ml | $364.00 | |||
Antibody (A-10) Alexa Fluor® 594 | sc-518143 AF594 | 200 µg/ml | $364.00 | |||
Antibody (A-10) Alexa Fluor® 647 | sc-518143 AF647 | 200 µg/ml | $364.00 | |||
Antibody (A-10) Alexa Fluor® 680 | sc-518143 AF680 | 200 µg/ml | $364.00 | |||
Antibody (A-10) Alexa Fluor® 790 | sc-518143 AF790 | 200 µg/ml | $364.00 |