Date published: 2025-12-18

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FOXP2 Inhibitors

FOXP2 inhibitors are a category of chemical compounds designed to specifically target and modulate the activity of the FOXP2 gene, which encodes for a transcription factor with significant implications in the field of genetics and neuroscience. FOXP2, short for Forkhead box P2, is a highly conserved transcription factor that plays a crucial role in the development and function of the human brain, particularly in language and speech-related processes. This gene is found on chromosome 7 in humans and is highly expressed in the basal ganglia, cortex, and other regions of the brain, indicating its importance in the central nervous system.

The development of FOXP2 inhibitors has garnered considerable attention from researchers interested in understanding the molecular mechanisms underlying language acquisition and speech production. By inhibiting FOXP2 activity, these compounds provide valuable tools for investigating the gene's role in neural development and function. They can help researchers uncover the intricate pathways and regulatory networks that involve FOXP2, shedding light on how genetic factors contribute to language-related disorders and cognitive functions. Moreover, FOXP2 inhibitors can be employed in animal studies to elucidate the gene's impact on brain development and communication, ultimately advancing our knowledge of the complex interplay between genetics and linguistic abilities.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

This compound is a DNA methyltransferase inhibitor, potentially reducing methylation of the FOXP2 gene promoter, leading to its downregulation.

Valproic Acid

99-66-1sc-213144
10 g
$85.00
9
(1)

Valproic Acid can inhibit histone deacetylases, possibly leading to altered chromatin states and reduced FOXP2 expression.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

This compound is known to interfere with RNA synthesis, and it may inhibit FOXP2 expression by disrupting its transcription or translation.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Actinomycin D binds to DNA and inhibits RNA polymerase, potentially leading to reduced FOXP2 expression by blocking its transcription.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin has been shown to modulate various signaling pathways and gene expressions. It may decrease FOXP2 expression by altering transcription factor activity or epigenetic modifications.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol is known to modulate various signaling pathways and could potentially decrease FOXP2 expression through alterations in transcription factor activity or epigenetic modifications.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$65.00
$210.00
26
(2)

By inhibiting glycolysis, 2-Deoxy-D-glucose may create a cellular environment that leads to reduced FOXP2 expression.

Hydroxyurea

127-07-1sc-29061
sc-29061A
5 g
25 g
$76.00
$255.00
18
(1)

Hydroxyurea disrupts DNA synthesis, and it could potentially lead to reduced FOXP2 expression by inhibiting its transcription.