Actinomycin D CAS: 50-76-0
MF: C62H86N12O16
MW: 1255.42
A potent antibiotic that binds to the GpC steps of DNA.

Actinomycin D (CAS 50-76-0)

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同义词: Oncostatin K; Actinomycin IV
应用; A potent antibiotic that binds to the GpC steps of DNA
CAS号码: 50-76-0
纯度: ≥98%
分子量: 1255.42
分子式: C62H86N12O16
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria. Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes, among others. This compound is also an RNA polymerase inhibitor. In studies it has been observed that Actinomycin D elevates p53 expression, leading to the increase of PUMAα/β (the p53 upregulated modulator of apoptosis protein; PUMA), and can also induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-dependent and -independent apoptosis.


参考文献

1. Bailey, S.A., et al. 1993. Biochemistry. 32: 5881-5887. PMID: 8504108
2. Verhaegen, S., et al. 1995. Biochem. Pharmacol. 50: 1021-1029. PMID: 7575657
3. Kalousek, I., et al. 2007. Anticancer Drugs. 18: 763-772. PMID: 17581298
4. Wang, M.J., et al. 2007. Neurosci. Res. 59: 40-46. PMID: 17707539
5. Xu, H. and Krystal, G.W. 2010. Clin Cancer Res. PMID: 20732961

物理状态 :
Solid
来源于 :
Streptomyces parvulus
溶解度 :
Soluble in DMSO (>20 mg/ml), 100% ethanol (1 mg/ml), methanol, chloroform, acetonitrile (9.80 - 10.20 mg/ml), and 1,2-Propanediol.
保存 :
Store at -20° C
熔点 :
251-253° C
沸点 :
1386.05° C at 760 mmHg (Predicted)
密度 :
1.43 g/cm3 (Predicted)
折射率 :
n20D 1.66 (Predicted)
光学活性 :
α28/D -315°, c = 0.25 in methanol
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
AU1575000
PubChem CID :
2019
默克索引 :
14: 2800
MDL 号码 :
MFCD00005033
EC号码 :
200-063-6
Beilstein 注册 :
605235
SMILES :
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

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引用1 - 1023

PMID: # 31222373  Luo, Y. et al. 2019. Cell. Mol. Life Sci.

PMID: # 30870073  Song, H.|Feng, X.|Zhang, H.|Luo, Y.|Huang, J.|Lin, M.|Jin, J.|Ding, X.|Wu, S.|Huang, H.|Yu, T.|Zhang, M.|Hong, H.|Yao, S.|Zhao, Y.|Zhang, Z.| et al. 2019. Autophagy. 15: 1419-1437.

PMID: # 30796352  Yang, F.|Jin, H.|Que, B.|Chao, Y.|Zhang, H.|Ying, X.|Zhou, Z.|Yuan, Z.|Su, J.|Wu, B.|Zhang, W.|Qi, D.|Chen, D.|Min, W.|Lin, S.|Ji, W.| et al. 2019. Oncogene. 38: 4755-4772.

PMID: # 30639474  Liu, Y.|Wei, W.|Hong, C.|Wang, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Mol. Immunol. 107: 10-20.

PMID: # 30821592  Peng, M.|Wang, J.|Tian, Z.|Zhang, D.|Jin, H.|Liu, C.|Xu, J.|Li, J.|Hua, X.|Xu, J.|Huang, C.|Huang, C.| et al. 2019. Autophagy.

PMID: # 31119302  Liu, Y.|Wei, W.|Wang, Y.|Wan, C.|Bai, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Inflamm. Res. 68: 597-611.

PMID: # 30873168  Figliuolo da Paz, V.|Jamwal, DR.|Gurney, M.|Midura-Kiela, M.|Harrison, CA.|Cox, C.|Wilson, JM.|Ghishan, FK.|Kiela, PR.| et al. 2019. Front Immunol. 10: 304.

PMID: # 30602711  Weiss, J.| et al. 2018. Molecules. 24:

PMID: # 30414569  Shu, Y.|Wu, K.|Zeng, Z.|Huang, S.|Ji, X.|Yuan, C.|Zhang, L.|Liu, W.|Huang, B.|Feng, Y.|Zhang, B.|Dai, Z.|Shen, Y.|Luo, W.|Wang, X.|Liu, B.|Lei, Y.|Ye, Z.|Zhao, L.|Cao, D.|Yang, L.|Chen, X.|Luu, HH.|Reid, RR.|Wolf, JM.|Lee, MJ.|He, TC.| et al. 2018. Mol Ther Nucleic Acids. 13: 556-567.

PMID: # 29684377  Tocchetti, GN. et al. 2018. Biochem. Pharmacol. 154: 118-126.

引用1 - 1023
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