Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
FOXC2 is a member of forkhead/winged helix transcription factor family, whose members serve as key regulators in embryogenesis and cell differentiation. FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition. Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity. FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro. FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), an autosomal dominant disorder that classically presents as lymphedema of the limbs, and double rows of eyelashes (distichiasis). Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, suggesting a requirement of FOXC2 for skeletal tissue development. FOXC2 interacts with FOXC1 in the Notch signaling pathway and in kidney and heart development.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
How would I know if this antibody is better for my experiment? I am working on human lung cancer cell lines.
Asked by: Sanjana
Thank you for your question. We have not yet tested this antibody in any human lung cancer cell lines. Please refer to the Western blot data on our website for the most current published data using this antibody. Please contact us for further support.
Answered by: Technical Support
Date published: 2019-09-11
Has there been any work done to demonstrate that this antibody does not cross-react on the similar FOXC1 protein?
Asked by: FOXC2 investigator
Thank you for your question. This monoclonal antibody is raised against a peptide that is specific for FOXC2 and does not cross react with FOXC1. However, this has not been experimentally confirmed.
Answered by: Technical Support
Date published: 2019-02-23
What application is the blocking peptide sc-515472 P appropriate for?
Asked by: Professor Griffin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here:
Rated 5 out of
Great specificity!I recently purchased this antibody for WB analysis of FOXC2 expression in murine tumor cell lines. A strong band was observed in wild-type tumor cells, and no band was observed in a FOXC2 knockout tumor cell line.