FOXC2 Antibody (D-8): sc-515472
- FOXC2 Antibody (D-8) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 333-357 within an internal region of FOXC2 of human origin
- recommended for detection of FOXC2 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-515472 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FOXC2 Antibody (D-8) for WB applications. These reagents are now offered in bundles with FOXC2 Antibody (D-8) (see ordering information below).
FOXC2 Antibody (D-8) is a mouse monoclonal IgG2b antibody that detects FOXC2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FOXC2 is a crucial member of the forkhead/winged helix transcription factor family, playing a significant role in regulating adipocyte metabolism by enhancing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway. This modulation helps counteract the adverse effects of obesity, particularly in high-fat diets, where increased FOXC2 levels can mitigate symptoms associated with excessive fat accumulation. Additionally, FOXC2 is essential for the early stages of chondrogenic differentiation, both in vivo and in vitro, highlighting FOXC2′s importance in developmental biology. Notably, FOXC2 haploinsufficiency is linked to Lymphedema-distichiasis (LD), an autosomal dominant disorder characterized by limb lymphedema and double rows of eyelashes, underscoring FOXC2′s clinical relevance. Furthermore, FOXC2 interacts with FOXC1 within the Notch signaling pathway, which is critical for kidney and heart development, indicating FOXC2′s multifaceted role in both normal physiology and disease states. Anti-FOXC2 antibody (D-8) is an invaluable tool for researchers investigating the intricate functions and interactions of this important transcription factor.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FOXC2 Antibody (D-8) | sc-515472 | 200 µg/ml | $322.00 | |||
FOXC2 Antibody (D-8): m-IgG Fc BP-HRP Bundle | sc-538792 | 200 µg Ab; 10 µg BP | $361.00 | |||
FOXC2 Antibody (D-8): m-IgGκ BP-HRP Bundle | sc-536462 | 200 µg Ab; 40 µg BP | $361.00 | |||
FOXC2 Antibody (D-8): m-IgG2b BP-HRP Bundle | sc-549986 | 200 µg Ab; 10 µg BP | $361.00 | |||
FOXC2 (D-8) Neutralizing Peptide | sc-515472 P | 100 µg/0.5 ml | $69.00 | |||
FOXC2 Antibody (D-8) X | sc-515472 X | 200 µg/0.1 ml | $322.00 |