FOXC2 Antibody (G-7): sc-515234

FOXC2 Antibody (G-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects FOXC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FOXC2 monoclonal antibody (G-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FOXC2, a member of the forkhead/winged helix transcription factor family, plays a crucial role in regulating adipocyte metabolism by enhancing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through modifications in the composition of the adipocyte PKA holoenzyme. This function is particularly important as increased levels of FOXC2, often induced by a high-fat diet, can mitigate many obesity-related symptoms, highlighting FOXC2′s potential as a therapeutic target in metabolic disorders. Additionally, FOXC2 is implicated in the early stages of chondrogenic differentiation, both in vivo and in vitro, and FOXC2 haploinsufficiency is linked to Lymphedema-distichiasis (LD), an autosomal dominant disorder characterized by limb lymphedema and double rows of eyelashes. Furthermore, studies have shown that FOXC2 is essential for skeletal tissue development, as evidenced by defects in axial and cranial skeletogenesis in mutant mice lacking FOXC2. Notably, FOXC2 interacts with FOXC1 within the Notch signaling pathway, which is vital for kidney and heart development, underscoring FOXC2′s multifaceted roles in both metabolic regulation and developmental processes.

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FOXC2 Antibody (G-7) References:

1. Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.  |  Kume, T., et al. 2000. Development. 127: 1387-95. PMID: 10704385
2. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome.  |  Fang, J., et al. 2000. Am J Hum Genet. 67: 1382-8. PMID: 11078474
3. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance.  |  Cederberg, A., et al. 2001. Cell. 106: 563-73. PMID: 11551504
4. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.  |  Kume, T., et al. 2001. Genes Dev. 15: 2470-82. PMID: 11562355
5. Bone morphogenetic protein regulation of forkhead/winged helix transcription factor Foxc2 (Mfh1) in a murine mesodermal cell line C1 and in skeletal precursor cells.  |  Nifuji, A., et al. 2001. J Bone Miner Res. 16: 1765-71. PMID: 11585339

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXC2 Antibody (G-7) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXC2 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXC2 Antibody (G-7) Specifications

Alternate Product Name: FOXC2

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 31-70

Epitope Target: FOXC2

Epitope Species: human

Product Reactivity/Detection: FOXC2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for FOXC2 Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin