FIGNL1 Antibody (F-11): sc-398667

FIGNL1 Antibody (F-11) is a mouse monoclonal IgG1 antibody that detects FIGNL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FIGNL1, or fidgetin-like 1, is a 674 amino acid protein belonging to the AAA ATPase family and exists as a hexamer, with alternative splicing resulting in two distinct isoforms. FIGNL1 plays a crucial role in cellular processes, particularly in regulating osteoblast proliferation and differentiation, which is vital for bone formation and maintenance. FIGNL1′s function is further underscored by phosphorylation in response to DNA damage, likely mediated by ATM or ATR kinases, highlighting involvement in cellular response to stress. The gene encoding FIGNL1 is located on human chromosome 7, a region associated with various genetic disorders, including Osteogenesis imperfecta and Shwachman-Diamond syndrome. FIGNL1′s significance extends beyond structural and functional attributes, as interactions with other proteins can influence critical pathways in cell biology, making anti-FIGNL1 antibody (F-11) an essential tool for researchers studying bone biology and related diseases.

The preferred FIGNL1 antibody is FIGNL1 Antibody (A-4): sc-398264.