FIGNL1 Antibody (A-4): sc-398264
- FIGNL1 Antibody (A-4) is a mouse monoclonal IgG2a κ FIGNL1 antibody provided at 200 µg/ml
- raised against amino acids 378-423 mapping within an internal region of FIGNL1 of human origin
- FIGNL1 Antibody (A-4) is recommended for detection of FIGNL1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FIGNL1 Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FIGNL1 Antibody (A-4). This work is in progress.
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FIGNL1 Antibody (A-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects FIGNL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FIGNL1 antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FIGNL1, or fidgetin-like 1, is a 674 amino acid protein that belongs to the AAA ATPase family and is known for its critical role in regulating cellular processes such as osteoblast proliferation and differentiation. FIGNL1 exists as a hexamer and undergoes alternative splicing to produce two isoforms, which adds complexity to functional roles in the cell. FIGNL1 utilizes magnesium as a cofactor and is phosphorylated in response to DNA damage, likely by ATM or ATR kinases, highlighting involvement in cellular response to stress and maintaining genomic integrity. FIGNL1 gene is located on human chromosome 7, a region associated with various genetic disorders, including Osteogenesis imperfecta and Shwachman-Diamond syndrome, underscoring potential implications in developmental and disease processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FIGNL1 Antibody (A-4) References:
- Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. | Mayer, H., et al. 2001. DNA Seq. 12: 161-6. PMID: 11762191
- The DNA sequence of human chromosome 7. | Hillier, LW., et al. 2003. Nature. 424: 157-64. PMID: 12853948
- EGFR amplification and lack of activating mutations in metaplastic breast carcinomas. | Reis-Filho, JS., et al. 2006. J Pathol. 209: 445-53. PMID: 16739104
- The neurobiology of Williams syndrome: cascading influences of visual system impairment? | Eckert, MA., et al. 2006. Cell Mol Life Sci. 63: 1867-75. PMID: 16810457
- Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. | Landlinger, C., et al. 2006. Biochim Biophys Acta. 1758: 1759-67. PMID: 16979580
- Structural aberrations of chromosome 7 revealed by a combination of molecular cytogenetic techniques in myeloid malignancies. | Brezinová, J., et al. 2007. Cancer Genet Cytogenet. 173: 10-6. PMID: 17284364
- LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. | Sturla, L., et al. 2009. J Biol Chem. 284: 28045-28057. PMID: 19667068
- Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta. | Tsipouras, P., et al. 1983. J Clin Invest. 72: 1262-7. PMID: 6313757
- Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci. | Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FIGNL1 Antibody (A-4) | sc-398264 | 200 µg/ml | $322.00 | |||
FIGNL1 Antibody (A-4) AC | sc-398264 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FIGNL1 Antibody (A-4) HRP | sc-398264 HRP | 200 µg/ml | $322.00 | |||
FIGNL1 Antibody (A-4) FITC | sc-398264 FITC | 200 µg/ml | $336.00 | |||
FIGNL1 Antibody (A-4) PE | sc-398264 PE | 200 µg/ml | $349.00 | |||
FIGNL1 Antibody (A-4) Alexa Fluor® 488 | sc-398264 AF488 | 200 µg/ml | $364.00 | |||
FIGNL1 Antibody (A-4) Alexa Fluor® 546 | sc-398264 AF546 | 200 µg/ml | $364.00 | |||
FIGNL1 Antibody (A-4) Alexa Fluor® 594 | sc-398264 AF594 | 200 µg/ml | $364.00 | |||
FIGNL1 Antibody (A-4) Alexa Fluor® 647 | sc-398264 AF647 | 200 µg/ml | $364.00 | |||
FIGNL1 Antibody (A-4) Alexa Fluor® 680 | sc-398264 AF680 | 200 µg/ml | $364.00 | |||
FIGNL1 Antibody (A-4) Alexa Fluor® 790 | sc-398264 AF790 | 200 µg/ml | $364.00 |