FHL-2 Antibody (E-8): sc-398866
- FHL-2 Antibody (E-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-57 mapping at the N-terminus of FHL-2 of human origin
- recommended for detection of FHL-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FHL-2 Antibody (E-8) for WB applications. These reagents are now offered in bundles with FHL-2 Antibody (E-8) (see ordering information below).
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FHL-2 Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects FHL-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FHL-2, a member of the four-and-a-half-LIM domain protein family, plays a crucial role in muscle development and function, particularly in cardiac and skeletal muscle, as well as in reproductive tissues like the placenta and ovary. FHL-2 localizes in the cytosol of myoblasts, myotubes, and differentiated myocytes, suggesting a regulatory function in muscle cell differentiation and signaling pathways. FHL-2 interacts with various transcription factors, including CREB and CREM, which are essential for gene expression regulation during muscle development. FHL-2′s ability to modulate these pathways highlights its importance in maintaining muscle integrity and function, making FHL-2 a valuable target for research in muscle-related diseases and developmental biology. Anti-FHL-2 antibody (E-8) serves as an essential tool for researchers investigating the roles of FHL proteins in various biological processes.
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FHL-2 Antibody (E-8) References:
- FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis. | Wixler, V., et al. 2015. Ann Rheum Dis. 74: 2216-23. PMID: 25125695
- LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression. | Dahan, J., et al. 2017. Mol Cell Biol. 37: PMID: 28223370
- FHL2 interacts with iASPP and impacts the biological functions of leukemia cells. | Lu, W., et al. 2017. Oncotarget. 8: 40885-40895. PMID: 28402264
- The LIM-Only Protein FHL2 is involved in Autophagy to Regulate the Development of Skeletal Muscle Cell. | Liu, Z., et al. 2019. Int J Biol Sci. 15: 838-846. PMID: 30906214
- FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy. | Li, SY., et al. 2019. Sci Rep. 9: 6693. PMID: 31040292
- Deletion of FHL2 in fibroblasts attenuates fibroblasts activation and kidney fibrosis via restraining TGF-β1-induced Wnt/β-catenin signaling. | Duan, Y., et al. 2020. J Mol Med (Berl). 98: 291-307. PMID: 31927599
- EphB3 interacts with initiator caspases and FHL-2 to activate dependence receptor cell death in oligodendrocytes after brain injury. | Tsenkina, Y., et al. 2020. Brain Commun. 2: fcaa175. PMID: 33305261
- c-Abl kinase regulates cell proliferation and ionizing radiation-induced G2/M arrest via phosphorylation of FHL2. | Wang, GF., et al. 2021. FEBS Open Bio. 11: 1731-1738. PMID: 33932144
- Downregulation of FHL2 suppressed trophoblast migration, invasion and epithelial-mesenchymal transition in recurrent miscarriage. | Luan, X., et al. 2024. Reprod Biomed Online. 48: 103342. PMID: 37945432
- FHL2 promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway. | Wang, S., et al. 2024. Thorac Cancer. 15: 630-641. PMID: 38323374
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FHL-2 Antibody (E-8) | sc-398866 | 200 µg/ml | $322.00 | |||
FHL-2 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-538532 | 200 µg Ab; 10 µg BP | $361.00 | |||
FHL-2 Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-536163 | 200 µg Ab; 40 µg BP | $361.00 |