FEZ1 Antibody (E-12): sc-393768

FEZ1 Antibody (E-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects FEZ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FEZ1 (E-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FEZ1, also known as leucine zipper putative tumor suppressor or LZTS1, plays a crucial role in regulating cell growth and is characterized by a DNA-binding leucine zipper motif. FEZ1 expression is vital in normal breast and prostate tissues, where FEZ1 functions as a negative regulator of cell proliferation. Loss of FEZ1 expression is frequently observed in breast and prostate cancer cell lines, as well as in primary tumors, which can be attributed to genetic mutations or hypermethylation of the CpG island surrounding the FEZ1 promoter. During cell-cycle progression, FEZ1 localizes to microtubule components and undergoes hyperphosphorylation by cAMP-dependent kinase, highlighting FEZ1′s importance in maintaining normal cellular functions and potential role in tumorigenesis. Frequent loss of heterozygosity at human chromosome 8p22-p21, where FEZ1 gene is located, has been associated with various malignancies, including prostate and breast cancer, underscoring FEZ1′s significance in cancer research and therapeutic development.

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FEZ1 Antibody (E-12) References:

1. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.  |  Ishii, H., et al. 1999. Proc Natl Acad Sci U S A. 96: 3928-33. PMID: 10097140
2. Fez1/lzts1 alterations in gastric carcinoma.  |  Vecchione, A., et al. 2001. Clin Cancer Res. 7: 1546-52. PMID: 11410489
3. Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22.  |  Cabeza-Arvelaiz, Y., et al. 2001. Oncogene. 20: 4169-79. PMID: 11464283
4. FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.  |  Ishii, H., et al. 2001. Proc Natl Acad Sci U S A. 98: 10374-9. PMID: 11504921
5. Homozygous deletions at 8p22 and 8p21 in prostate cancer implicate these regions as the sites for candidate tumor suppressor genes.  |  Kagan, J., et al. 1995. Oncogene. 11: 2121-6. PMID: 7478532
6. Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer.  |  Macoska, JA., et al. 1995. Cancer Res. 55: 5390-5. PMID: 7585607
7. Allelic loss of chromosomal arm 8p in breast cancer progression.  |  Anbazhagan, R., et al. 1998. Am J Pathol. 152: 815-9. PMID: 9502423

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FEZ1 Antibody (E-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-FEZ1 Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FEZ1 Antibody (E-12) Specifications

Alternate Product Name: FEZ1

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 577-604

Epitope Target: FEZ1

Epitope Species: human

Product Reactivity/Detection: FEZ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for FEZ1 Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin